Using Virtual Reality and Aromatherapy to Ease Pain and Anxiety During Prostate Biopsy

A Randomized, Controlled Trial: Impact on Patient Experience in Patients Assigned to Virtual Reality Headset; Aromatherapy Patch; Virtual Reality + Aromatherapy; or Standard of Care for Transperineal Prostate Biopsy

Not applicable Interventional University of Pittsburgh · NCT06296147

This study is testing if using virtual reality and/or aromatherapy can help men feel less pain and anxiety during a prostate biopsy.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment208 (estimated)
Ages18 Years and up
SexMale
SponsorUniversity of Pittsburgh Academic / other
Locations1 site (Pittsburgh, Pennsylvania)
Trial IDNCT06296147 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of a virtual reality (VR) headset and/or aromatherapy in reducing pain, anxiety, and embarrassment for patients undergoing a transperineal prostate biopsy. Participants will be randomly assigned to one of four groups: VR, aromatherapy, a combination of both, or standard care. The primary outcome will be measured through self-reported surveys immediately after the procedure, comparing the experiences of patients in each group. The goal is to determine if these non-anesthetic interventions can improve patient comfort during the biopsy process.

Who should consider this trial

Good fit: Ideal candidates are adult males aged 18 and older who are scheduled for a transperineal prostate biopsy.

Not a fit: Patients with psychiatric conditions, severe sensory impairments, or a history of seizures may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly enhance patient comfort and reduce anxiety during prostate biopsies.

How similar studies have performed: While the use of VR and aromatherapy in medical settings is gaining attention, this specific combination for prostate biopsy is relatively novel and has not been extensively tested.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patient is 18 years or older
* Patient is male
* Patient is due for a transperineal prostate biopsy
* Patient signed and dated informed consent form on Redcap agreeing to participate in the study

Exclusion Criteria:

* Patient has a known psychiatric or mental illness that would impede use of the VR device or aromatherapy patch
* Patient has severe hearing or vision problems that would impair use of the VR headset (under the physician's discretion)
* Patient has a history of seizures or epilepsy or is on a medication that would lower the threshold for a seizure
* Patient has a history of reactions to noxious odors

Where this trial is running

Pittsburgh, Pennsylvania

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Prostate CancerTransperineal Prostate Biopsy
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.