Using virtual bronchoscopic navigation to improve diagnosis of lung nodules
Official title: Virtual Bronchoscopic Navigation to Increase Diagnostic Yield in Patients With Pulmonary Nodules
Run by University Medical Center Groningen · NCT05383105 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study tests if a new method using virtual bronchoscopic navigation can help doctors diagnose lung nodules more safely and effectively than traditional procedures.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University Medical Center Groningen Academic / other |
| Locations | 1 site (Groningen) |
| Trial ID | NCT05383105 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 with suspicious pulmonary nodules larger than 6 mm that are accessible via bronchoscopy.
✕Probably not a fit
Patients with contraindications for bronchoscopy or general anesthesia, or those with severe pulmonary conditions, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study evaluates the effectiveness of virtual bronchoscopic navigation (VBN) in diagnosing solitary pulmonary nodules (SPN) that may be cancerous. The study aims to compare the diagnostic yield of VBN with traditional transthoracic CT-guided procedures, which carry a higher risk of complications. By utilizing a transparenchymal approach, the study seeks to safely access small or difficult-to-reach nodules located in the inner two-thirds of the lung. Participants will be monitored for the success of the procedure and any associated complications.
Why it matters
Potential benefit: If successful, this approach could lead to safer and more accurate diagnoses of lung nodules, potentially improving patient outcomes.
How similar studies have gone: Previous studies have shown promising results with similar endobronchial techniques, suggesting potential for success in this novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age \>18 * pulmonary nodule(s) suspicious for malignancy or metastases of a known primary tumour * a distinct nodule with a diameter of \>6 mm in its largest dimension * nodule located in the parenchymal tissue \>1 cm from the pleura and bronchoscopically accessible through a point of entry * willing to give informed consent to the procedure. Exclusion Criteria: * any contraindication to undergo bronchoscopy * contraindication for general anaesthesia * inability to stop anticoagulants or antiplatelets agents according to the UMCG protocol * childbearing or breastfeeding women * moderate to seyere pulmonary fibrosis * severe emphysema with bullae \> 5 cm m the vicinity of the target nodule or tunnel.
Where it's running
-
UMCG Groningen
Groningen, Netherlands Recruiting
Study contacts
- Principal investigator: Dirk-Jan Slebos, MD PhD — UMCG Groningen, The Netherlands
- Study coordinator: Dirk-Jan Slebos, MD PhD
- Email: d.j.slebos@umcg.nl
- Phone: +31503612357
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Autologous NK cell therapy KN5001 for pulmonary nodules.
This test tries KN5001, made from your own NK cells, to see if it is safe and can help adults (18–70) who have malignant or high‑risk lung nodules that cannot be removed surgically or have failed other treatments.
-
Using breath analysis to differentiate between benign and malignant lung nodules
This study is testing whether analyzing breath samples can help tell the difference between harmless and cancerous lung nodules in people who have been diagnosed with them.
-
Can FAPI or FDG PET/CT help diagnose active Peyronie's disease
This study tests whether FAPI-PET/CT or FDG-PET/CT scans can detect active inflammation or fibroblast activity in men with Peyronie’s disease.
-
PEM: a starting point to understand ME/CFS
Researchers are studying post-exertional malaise to better understand ME/CFS in adults who report persistent fatigue and PEM.
-
Isoniazid inhalation in TB patients: a first-in-human look at local tolerability and body levels
This early study tests inhaled isoniazid to see how well it tolerates the lungs and how it behaves in the body in adults with tuberculosis.
-
Neoadjuvant nivolumab for cervical cancer using tumor-draining lymph nodes
This study tests different doses of nivolumab injected near the tumor to see if the treatment is safe and feasible before standard surgery in newly diagnosed cervical cancer.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.