Using virtual and augmented reality for vestibular therapy in mild traumatic brain injury

Use of Virtual and Augmented Reality Devices in Vestibular Physical Therapy for mTBI

Not applicable Interventional Naval Health Research Center · NCT05326100

This study is testing if virtual and augmented reality treatments can help servicemembers with balance problems and symptoms from mild traumatic brain injuries feel better compared to regular therapy.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment36 (estimated)
Ages18 Years to 65 Years
SexAll
SponsorNaval Health Research Center Federal
Locations3 sites (San Diego, California and 2 other locations)
Trial IDNCT05326100 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness of virtual reality (VR) and augmented reality (AR) technologies in improving functional status and reducing symptoms in servicemembers with vestibular disorders resulting from mild traumatic brain injury (mTBI). Participants will be randomly assigned to one of three treatment groups: conventional vestibular therapy, VR therapy using the CAREN system, or AR therapy using a head-mounted display. The study will measure outcomes such as balance and symptom severity using validated assessment tools. The goal is to determine if advanced VR and AR therapies provide superior benefits compared to traditional therapy methods.

Who should consider this trial

Good fit: Ideal candidates for this study are active duty servicemembers aged 18 to 65 with a history of mild traumatic brain injury and vestibular dysfunction.

Not a fit: Patients with a history of moderate or severe traumatic brain injury may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could significantly enhance rehabilitation outcomes for patients with vestibular dysfunction following mTBI.

How similar studies have performed: Other studies have shown promise in using VR and AR technologies for rehabilitation, suggesting potential success for this innovative approach.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men and women, active duty SMs between 18 and 65 years of age and enrolled in Defense Enrollment Eligibility Reporting System (DEERS)
* History of mTBI based on the Ohio State University Traumatic Brain Injury Identification (OSU TBI-ID)
* Require vestibular physical therapy as determined by a PT
* Normal or corrected vision based on the Snellen Eye Chart of at least 20/40
* Able to consistently follow verbal and written instructions and observe safety precautions
* Able to tolerate up to 60 minutes of physical therapy exercise, with breaks
* Able to ambulate with contact guard assistance or less, and to walk unassisted over ground or on a treadmill for 10 minutes at a time
* Able to tolerate wearing a full body safety harness
* Able to tolerate wearing a head mounted display weighing up to 3 pounds for up to 60 minutes

Exclusion Criteria:

* History of a moderate or severe TBI (OSU TBI-ID; or DVBIC TBI Screening Tool)
* Under care of a physician for a neurodegenerative diagnosis
* History of seizures or syncope
* Clinical determination of Benign Paroxysmal Positional Vertigo (BPPV)
* Diagnosis of any of the following visual impairments: field cuts, macular degeneration, retinal detachment, diplopia, limited peripheral or central vision, or require prism lenses
* Unable or unwilling to use contacts for corrected vision
* Require a medical device that can be affected by radio waves such as a pacemaker, defibrillator, or hearing devices (implantable or air conduction)
* Medications with significant sedating side effects that could impact safety (i.e., Phenobarbital, Ativan, etc.)
* Women who are more than 4 months pregnant may not participate in this study due to the effects advanced pregnancy can have on balance and vision. Note: Women who choose to participate will be informed up front that there are risks associated with pregnancy including decrements in postural control and falls. Additionally, changes in hormones, metabolism, fluid retention, and blood circulation during pregnancy can affect the eyes and eyesight. Women who become pregnant during the intervention should inform their PT immediately to determine if continued participation is possible.
* Concurrent participation, either clinically and/or as a part of another research study, in vestibular physical therapy and/or PTSD treatment
* Unable to consent for any reason

Where this trial is running

San Diego, California and 2 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions MTBI - Mild Traumatic Brain InjuryDysfunction of Vestibular SystemVirtual RealityAugmented RealityVestibular Physical TherapyComputer Assisted Rehabilitation EnvironmentHead Mounted DisplayPhysical Therapy
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.