Using vancomycin to prevent infections after hip and knee surgeries
Can Topical Vancomycin Prevent Periprosthetic Joint Infection in Primary Hip and Knee Arthroplasty? Multicenter Randomized Controlled Trial
NA · Independent Public Healthcare Center in Rypin · NCT05972603
This study is testing if using vancomycin powder along with a special cleaning solution can help prevent infections in people having hip and knee replacement surgeries.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Independent Public Healthcare Center in Rypin (other) |
| Locations | 1 site (Rypin, Kujawsko-pomorksie) |
| Trial ID | NCT05972603 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of a protocol involving vancomycin powder and diluted povidone-iodine lavage in reducing the rates of periprosthetic joint infections (PJI) following primary total hip and knee arthroplasties. Patients undergoing these surgeries will receive a specific lavage solution before closure, followed by the application of vancomycin powder around the prosthesis. The goal is to determine if this VIP protocol is more effective than the standard diluted povidone-iodine protocol in preventing infections.
Who should consider this trial
Good fit: Ideal candidates are patients undergoing total hip or knee arthroplasty due to osteoarthritis or rheumatoid arthritis.
Not a fit: Patients undergoing arthroplasty for reasons other than osteoarthritis, rheumatoid arthritis, or avascular necrosis may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of infections in patients undergoing hip and knee arthroplasties.
How similar studies have performed: While the specific VIP protocol is novel, similar studies have shown that antibiotic prophylaxis can reduce infection rates in surgical procedures.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * undergoing THA or TKA as a result of osteoarthritis or rheumatoid arthritis, can understand and comply with the study protocol, have signed the informed consent document at screening Exclusion Criteria: * Patients referred to the hospital in order to undergo THA or TKA due to different reason than osteoarthritis, rheumatoid arthritis or avascular necrosis of the femoral head, such as: failed femoral neck fractures, displaced acetabular fractures or revision acetabular fractures, revision knee or hip arthroplasty
Where this trial is running
Rypin, Kujawsko-pomorksie
- IPHC Rypin — Rypin, Kujawsko-pomorksie, Poland (RECRUITING)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Osteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis of Hip