Using Vancomycin Powder to Prevent Infections After Spinal Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study compares the effectiveness of standard antibiotic treatment with the addition of intra-wound Vancomycin powder in preventing surgical site infections following spinal surgery. Patients undergoing posterior spinal fusion at the Rabin Medical Center will be enrolled and receive either the standard treatment or the additional Vancomycin. The study aims to identify the optimal dosage of Vancomycin while all participants will also receive routine intravenous antibiotic prophylaxis. The goal is to determine if the use of Vancomycin can significantly reduce wound-related complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing posterior spinal fusion operation at the neurosurgery department at the Rabin Medical Center
* Ability to understand and sign written informed consent by the patient or legal guardian

Exclusion Criteria:

* Preoperative ongoing infectious disease present as judged by the primary surgeon (based on lab results and clinical assessment)
* Receiving ongoing treatment of antibiotics for other infections
* Sensitivity or allergy to vancomycin or cefazolin
* Previous spine surgery at the index level within the last 90 days
* Postoperative radiotherapy of the surgical site required (e.g. for tumor)
* Renal insufficiency with stage 4 chronic kidney disease (CKD) with a glomerular filtration rate (GFR) of 15-30 ml/min or worse
* Undergoing spinal decompression only
* Trauma patients
* Pregnancy

Where it's running

• Rabin Medical Center
  Petah Tikva, Israel Recruiting

Study contacts

• Principal investigator: Eyal Itshayek, MD — Rabin Medical Center
• Study coordinator: Eyal Itshayek, MD
• Email: eyal.itshayek@gmail.com
• Phone: +972-50-8946921

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.