Using Valacyclovir to Manage Pain from Dental Abscesses
Valacyclovir Monotherapy in Pain Management of Acute Apical Abscesses After Performing Emergency Chamber Opening; A Randomized Clinical Trial
PHASE4 · Dow University of Health Sciences · NCT06344195
This study is testing if the medication valacyclovir can help reduce pain after dental abscess surgery compared to standard pain relief with naproxen.
Quick facts
| Phase | PHASE4 |
|---|---|
| Study type | Interventional |
| Enrollment | 82 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Dow University of Health Sciences (other) |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT06344195 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of valacyclovir in alleviating postoperative pain in patients with acute apical abscesses following emergency chamber opening. A total of 82 participants will be divided into two groups: one receiving valacyclovir and the other receiving standard treatment with naproxen sodium. Pain levels will be assessed using a numeric rating scale over a period of six days. The study aims to determine if valacyclovir can reduce pain and the reliance on analgesics in these patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with moderate to severe pain due to acute apical abscess and pulp necrosis.
Not a fit: Patients currently on antibiotics or antivirals, smokers, or those with specific dental conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could provide a new option for pain management in patients suffering from acute apical abscesses.
How similar studies have performed: While the use of valacyclovir in this context is novel, other studies have explored antiviral treatments for dental pain with varying results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient Age ≥18 years old * Healthy patient American Society of Anesthesiologists (ASA) class l and ll. * Patients having clinical evidence of pulp necrosis and acute apical abscess with radiographic signs of periapical disease. * Main inclusion criteria is that patient should have moderate to severe pain, it can be calculated as: 1 to 3 as Mild pain. 4 to 6 as moderate pain. 7 to 10 as severe pain. Exclusion Criteria: * Patient currently on antibiotics or antivirals * Smokers * Unusual tooth anatomy or inaccurate diagnosis * Pregnant or nursing mothers * Patients allergic to valacyclovir
Where this trial is running
Karachi, Sindh
- Dr. Yumna Shaheen Ali — Karachi, Sindh, Pakistan (RECRUITING)
Study contacts
- Principal investigator: Dr. Yumna Shaheen Ali — DUHS
- Study coordinator: Dr. Yumna Shaheen Ali
- Email: yumna.shaheen@duhs.edu.pk
- Phone: 03321349223
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Acute Apical Abscess, Valacyclovir Monotherapy, Antiviral drug therapy, Emergency chamber opening, Dental Pain