Using umbilical cord blood to support stem cell transplants for treating aplastic anemia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety and feasibility of using umbilical cord blood in haploidentical hematopoietic stem cell transplantation (haplo-HSCT) for patients with aplastic anemia. Participants will be divided into two groups: one receiving traditional HLA-matched HSCT and the other receiving the umbilical cord blood-supported haplo-HSCT. The goal is to compare outcomes, particularly hematopoietic recovery and overall prognosis, between the two approaches. Aplastic anemia is a serious condition, and this innovative method aims to improve treatment options for patients who struggle to find matched donors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* A patient age of 6-75 years
* Patients diagnosed with Severe Aplastic Anemia (SAA) , Transfusion-Dependent Non-Severe Aplastic Anemia (TD-NSAA) or Paroxysmal nocturnal hemoglobinuria (PNH) acquired clonal-aplastic anemia(AA) according to the Chinese Guidelines for the Diagnosis and Treatment of Aplastic Anemia (2022 Edition) and suitable for allo-HSCT
* Subjects (or their legally acceptable representatives) must have signed an informed consent document indicating that they understand the purpose of and procedures required for the study and are willing to participate in the study

Exclusion Criteria:

* Any abnormality in a vital sign (e.g., heart rate, respiratory rate, or blood pressure)
* Patients with any conditions not suitable for the trial (investigators' decision)

Where it's running

• Shanxi Bethune Hospital
  Taiyuan, Shanxi, China Recruiting

Study contacts

• Study coordinator: Tao Wang, Dr.
• Email: wangtao99699@163.com
• Phone: 13835175119

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.