Using ultrasound to predict successful weaning from mechanical ventilation
Role of Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning From Mechanical Ventilation
This study is testing if using ultrasound to measure how well the diaphragm is working can help doctors know when to safely take patients off mechanical ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 55 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Mansoura University Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Al Mansurah) |
| Trial ID | NCT06465082 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of measuring diaphragmatic thickening fraction via ultrasound as a predictor for successful weaning from mechanical ventilation. Proper timing for weaning is crucial, as premature or delayed weaning can lead to significant complications. Traditional methods for assessing diaphragm function have limitations, including invasiveness and exposure to radiation. Ultrasound offers a safe, non-invasive alternative that can be performed at the bedside, making it a practical tool for clinicians.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old who require mechanical ventilation due to life-threatening hypoxia or other severe respiratory issues.
Not a fit: Patients under 18, pregnant individuals, or those with specific medical conditions like neuromuscular diseases or diaphragmatic paralysis may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved weaning outcomes and reduced complications for patients on mechanical ventilation.
How similar studies have performed: Previous studies have indicated that assessing diaphragmatic function is critical for weaning, but the use of ultrasound for this purpose is a relatively novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients \>18 years old, who are in need for mechanical ventilation as: Life threatening hypoxia, Respiratory rate \> 30 breath/min, Disturbed conscious level. Exclusion Criteria: * Age \<18 years. * Pregnancy * Surgical incisions likely to interfere with ultrasound examination. * Hepato-splenomegaly, Ascites * Neuromuscular disease as Myasthenia gravis, kypho-scoliosis * Diaphragmatic Paralysis (paralyzed diaphragm exhibiting abnormal paradoxical movement, i.e., moving in a cranial direction during inspiration
Where this trial is running
Al Mansurah
- Mohamed AbdElmoniem — Al Mansurah, Egypt (Recruiting)
Study contacts
- Principal investigator: Mohamed AbdElmoniem — Mansoura University
- Study coordinator: Mohamed AbdElmoniem
- Email: dr.m1993@mans.edu.eg
- Phone: 01014008473
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.