Using ultrasound to predict successful weaning from mechanical ventilation
Official title: Role of Diaphragmatic Thickening Fraction as a Predictor of Successful Weaning From Mechanical Ventilation
Run by Mansoura University Hospital · NCT06465082 · Data updated 2026-11-12
This study is testing if using ultrasound to measure how well the diaphragm is working can help doctors know when to safely take patients off mechanical ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 55 (estimated) |
| Sponsor | Mansoura University Hospital Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Al Mansurah) |
| Status | Recruiting |
| Started | September 5, 2024 |
| Main results expected | July 15, 2025 |
| Study ends | December 15, 2025 |
| Registry record updated | May 29, 2025 |
| Trial ID | NCT06465082 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 years old who require mechanical ventilation due to life-threatening hypoxia or other severe respiratory issues.
✕Probably not a fit
Patients under 18, pregnant individuals, or those with specific medical conditions like neuromuscular diseases or diaphragmatic paralysis may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of measuring diaphragmatic thickening fraction via ultrasound as a predictor for successful weaning from mechanical ventilation. Proper timing for weaning is crucial, as premature or delayed weaning can lead to significant complications. Traditional methods for assessing diaphragm function have limitations, including invasiveness and exposure to radiation. Ultrasound offers a safe, non-invasive alternative that can be performed at the bedside, making it a practical tool for clinicians.
Why it matters
Potential benefit: If successful, this approach could lead to improved weaning outcomes and reduced complications for patients on mechanical ventilation.
How similar studies have gone: Previous studies have indicated that assessing diaphragmatic function is critical for weaning, but the use of ultrasound for this purpose is a relatively novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients \>18 years old, who are in need for mechanical ventilation as: Life threatening hypoxia, Respiratory rate \> 30 breath/min, Disturbed conscious level. Exclusion Criteria: * Age \<18 years. * Pregnancy * Surgical incisions likely to interfere with ultrasound examination. * Hepato-splenomegaly, Ascites * Neuromuscular disease as Myasthenia gravis, kypho-scoliosis * Diaphragmatic Paralysis (paralyzed diaphragm exhibiting abnormal paradoxical movement, i.e., moving in a cranial direction during inspiration
Where it's running
-
Mohamed AbdElmoniem
Al Mansurah, Egypt Recruiting
Study contacts
- Principal investigator: Mohamed AbdElmoniem — Mansoura University
- Study coordinator: Mohamed AbdElmoniem
- Email: dr.m1993@mans.edu.eg
- Phone: 01014008473
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Characterization of weaning practices in ICUs in Global South countries
This observational study tests how adult ICU patients on mechanical ventilation who are starting to wean are extubated, observing them for 7 days after extubation and until hospital discharge or death.
-
Doxapram to improve diaphragm movement during spontaneous breathing trials in ventilated COPD patients
This trial will test whether giving IV doxapram helps the diaphragm move more in people with moderate to severe COPD who are on a ventilator and doing a spontaneous breathing trial.
-
High-flow oxygen therapy for patients weaning off mechanical ventilation
This study tests if high-flow oxygen therapy can help patients with tracheostomies breathe easier and clear mucus better while they are transitioning off mechanical ventilation.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.