Using ultrasound to predict failure of high-flow nasal cannula therapy
Ultrasound Evaluations of Diaphragm and Intercostal Muscle to Predict the Failure of High-Flow Nasal Cannula Therapy
This study is testing if ultrasound can help doctors see how well certain muscles are working to predict if patients will struggle with high-flow nasal cannula oxygen therapy in the first day of treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai) |
| Trial ID | NCT06375538 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates diaphragm and intercostal muscle contractions using ultrasound to predict the failure of high-flow nasal cannula oxygenation therapy within the first 24 hours of treatment. By assessing muscle function, the study aims to identify patients who may not respond well to this therapy. The findings could help clinicians make timely decisions regarding patient management and intervention. The study is conducted at Shanghai Zhongshan Hospital.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 years old who require high-flow nasal cannula oxygenation therapy.
Not a fit: Patients who have received mechanical ventilation recently, have neuromuscular disorders, or are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance patient outcomes by allowing for early identification of those at risk of therapy failure.
How similar studies have performed: While similar approaches have been explored, this specific use of ultrasound for predicting therapy failure is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * more than 18 years old * needing High-flow Nasal Cannula oxygenation therapy Exclusion Criteria: * received mechanical ventilation, including invasive or noninvasive ventilation within one month prior to enrollment * history of neuromuscular disorders (e.g., myasthenia gravis, Guillain-Barre syndrome); * immediate endotracheal intubation is required (life-threatening hypoxemia) * extensive damage to the thoracic skin (e.g., burns) unable to undergo ultrasonography * pregnancy * attending physician deemed it inappropriate to participate in the trial.
Where this trial is running
Shanghai, Shanghai
- Shanghai Zhongshan Hospital — Shanghai, Shanghai, China (Recruiting)
Study contacts
- Principal investigator: Ming Zhong — Shanghai Zhongshan Hospital
- Study coordinator: Wei Wu
- Email: wu.wei1@zs-hospital.sh.cn
- Phone: 13817976707
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.