Using ultrasound to measure optic nerve sheath diameter for detecting high intracranial pressure

Ultrasonography of Optic Nerve Sheath Diameter for Noninvasive Detection of Raised Intracranial Pressure: a Chinese Multicenter Study

This study is testing if measuring the optic nerve sheath diameter with ultrasound can help doctors detect high pressure inside the skull in a Chinese population.

Quick facts

• Study type: Observational
• Enrollment: 1000 (estimated)
• Ages: 18 Years to 80 Years
• Sex: All
• Sponsor: The First Hospital of Jilin University (Academic / other)
• Locations: 1 site (Changchun, Jilin)
• Trial ID: NCT04981548 on ClinicalTrials.gov

What this trial studies

This observational study aims to establish the normal range of optic nerve sheath diameter (ONSD) in a Chinese population and to evaluate its effectiveness in diagnosing raised intracranial pressure. It will involve a large multi-center sample size, comparing data from patients with high intracranial pressure to those with normal levels. The study will analyze the correlation between ONSD measurements and intracranial pressure levels, utilizing transcranial Doppler parameters and baseline data. No interventions will be administered, as the focus is on observational data collection.

Who should consider this trial

Good fit: Ideal candidates include individuals requiring lumbar puncture testing due to conditions like brain trauma, infections, vascular diseases, or tumors, as well as healthy individuals for comparison.

Not a fit: Patients with eye diseases or those who cannot provide informed consent may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide a noninvasive method for early detection of raised intracranial pressure, improving patient outcomes.

How similar studies have performed: Other studies have shown promise in using ONSD measurements for assessing intracranial pressure, indicating that this approach is supported by existing research.

Eligibility criteria

Inclusion Criteria:

1. People requiring lumbar puncture testing due to brain trauma, intracranial infection, intracranial vascular disease, intracranial tumors, peripheral neuropathy for the raised intracranial pressure group.
2. Healthy people for the normal intracranial pressure group.

Exclusion Criteria:

1. eye diseases, such as eye trauma, eye tumors, optic neuritis, and glaucoma
2. People with poor temporal window penetration.
3. Patients who refuse to sign informed consent.

Where this trial is running

Changchun, Jilin

• the first hospital of Jilin university — Changchun, Jilin, China (Recruiting)

Study contacts

• Study coordinator: Sibo Wang, PhD

Conditions Ultrasonography; optic nerve sheath diameter; intracranial pressure