Using ultrasound to measure liver stiffness and fat content
Real-time Elastography for Non-invasive Assessment of Liver Fibrosis and Fat Quantification Techniques for Assessment of Fatty Change in Chronic Liver Disease
This study is testing if ultrasound can safely measure liver stiffness and fat levels in people with chronic liver disease instead of using a more invasive liver biopsy.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | King's College Hospital NHS Trust Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT06111859 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of ultrasound-based elastography and fat quantification techniques in assessing liver stiffness and fat levels in patients with chronic liver disease. By recruiting 100-120 participants, the study aims to provide a non-invasive alternative to liver biopsy, which carries significant risks and limitations. The ultrasound methods are designed to be safe and well-accepted by patients, potentially offering more accurate insights into liver health without the need for invasive procedures. The study will analyze the correlation between ultrasound measurements and liver conditions such as fibrosis and fatty liver disease.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with suspected chronic liver disease.
Not a fit: Patients who have undergone liver transplantation within the last six months or have acute liver disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a safer, non-invasive method for monitoring liver health and guiding treatment decisions for patients with chronic liver disease.
How similar studies have performed: Early studies using similar ultrasound-based techniques have shown promising results, indicating that this approach may be effective.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. \>=18 years old 2. Male or Female 3. Suspected chronic liver disease based on clinical history, serum biochemistry, prior imaging or prior liver biopsy 4. Willing and able to provide written informed consent. Exclusion Criteria: 1. Liver transplantation within the last six months 2. Suspected or known acute liver disease 3. Focal liver lesion(s) 4. Age \<18 years old 5. Pregnant women
Where this trial is running
London
- Nuran Seneviratne — London, United Kingdom (Recruiting)
Study contacts
- Study coordinator: Cheng Fang
- Email: chengfang@nhs.net
- Phone: 07809747718
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.