Using ultrasound to manage heart failure in outpatient settings

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The AMBUSH study is a multicenter, randomized, controlled clinical trial that aims to evaluate the effectiveness of therapeutic management guided by pulmonary ultrasound and inferior vena cava assessment in patients with heart failure. Participants will be monitored for changes in natriuretic peptides and clinical outcomes over a 30-day period. The study will compare the outcomes of patients receiving ultrasound-guided treatment to those receiving standard care without ultrasound. Secondary objectives include assessing the risk of cardiovascular events and the relationship between ultrasound findings and serum biomarker levels.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male or female aged 18 and over
* Heart failure (regardless of left ventricular ejection fraction)
* Diagnosis of heart failure established more than 3 months ago
* Absence of significant clinical signs of congestion on clinical examination (absence of crackles and lower limbs oedema greater than perimalleolar oedema)
* Affiliation to social security
* Receiving complete information about research organization and signed informed consent.

Exclusion Criteria:

* Natriuretic peptides result, carried out during the previous 30 days, available at the inclusion consultation
* Pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis.
* Suspicion of cardiac amyloidosis or proven amyloidosis,
* Patient with severe primary heart valve disease
* Pregnant woman, parturient or nursing mother
* Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
* Person deprived of liberty by a judicial or administrative decision,
* Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code.

Where it's running

• CHRU de Nancy
  Vandœuvre-lès-Nancy, France Recruiting
• CHU de Besançon
  Besançon, France Not yet recruiting
• CH de Mulhouse
  Mulhouse, France Not yet recruiting
• CHRU de Reims
  Reims, France Not yet recruiting
• CHR de Metz
  Thionville, France Not yet recruiting

Study contacts

• Study coordinator: Nicolas GIRERD, MD,PhD
• Email: n.girerd@chru-nancy.fr
• Phone: +33 3 83 15 74 96

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.