Using Transcranial Magnetic Stimulation to Treat Misophonia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to evaluate the effectiveness of parietal transcranial magnetic stimulation (TMS) in individuals suffering from misophonia. A total of 60 participants will undergo two sessions of TMS, one designed to inhibit and the other to excite brain activity in the parietal region. Participants will complete computerized tasks before and after each session while their EEG, heart rate, and skin temperature are monitored. The goal is to determine if TMS can enhance tolerance to specific sound triggers associated with misophonia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear.
* Must be between the ages of 18 - 55.
* Must be fluent in English since the study's instructions, surveys, and tasks will be in English.

Exclusion Criteria:

* Epilepsy or previous episode of convulsion or seizure.
* Previous episode of fainting spell or syncope.
* Head trauma.
* Hearing problems.
* Cochlear implant.
* Metal in the brain, skull, or anywhere else in the body (e.g., splinters, fragments, clips, etc.).
* Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS).
* Presence of cardiac pacemaker or intracardiac lines.
* Presence of medication infusion device.
* Use of pro-convulsant or epileptogenic medications.
* Pregnancy. The risks associated with TMS exposure during gestation have not been studied extensively. We wish to safeguard the health of potential participants and their children.
* Lactation. The risks associated with TMS during lactation and its effects on infant development have not been studied. We wish to safeguard the health of potential participants and their children.
* Presence of Mania, Psychosis, Antisocial Personality Disorder, Borderline Personality Disorder, and Suicidal Ideation.

Where it's running

• Mount Sinai West
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Daniela Schiller, PhD — Icahn School of Medicine at Mount Sinai
• Study coordinator: Shama Patel
• Email: shama.patel@mssm.edu
• Phone: 347-670-4878

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• How common misophonia is among high school students in Kayseri and Samsun, Turkey

  This project will use a short questionnaire to see how common and how severe misophonia is among high school students in Kayseri and Samsun, Turkey.

  Recruiting at 2 sites Ondokuz Mayıs University · Kayseri and 1 other locations · NCT07469033

• One-time 20 mg propranolol to reduce misophonia reactions

  This will test whether a single 20 mg oral dose of propranolol can temporarily reduce the emotional and physical reactions of adults (18–65) with clinically significant misophonia.

  Recruiting Early Phase 1 Bloom Mental Health, LLC · Littleton, Colorado · NCT07271485

• Effects of a Mindfulness App on Mental Health in Children with Tinnitus and Misophonia

  This study is testing if a virtual reality mindfulness app can help improve mental health for kids aged 10 to 18 who have severe tinnitus and misophonia.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06493825

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.