Using Transcranial Doppler to Detect and Reduce Emboli During Carotid Stenting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Transcranial Doppler (TCD) ultrasound will be used during the carotid stent procedure and in the immediate postoperative period to detect microembolic signals and, when possible, deliver ultrasound-enhanced thrombolytic effects. Eligible participants are adults with severe internal carotid artery stenosis who have an adequate temporal bone window and are scheduled for carotid artery stenting. The study will track perioperative cerebral emboli, new brain infarctions on imaging, and short-term neurological outcomes after the procedure. The approach builds on prior trials that suggested TCD monitoring may lower the rate of new infarctions during carotid procedures and aims to see if similar benefits occur in this patient group.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 40 years old;
* Patients with severe stenosis of the internal carotid artery;
* Planned for carotid artery stent;
* Modified Rankin Scale score ≤ 2;
* The subject has adequate temporal bone windows to undergo TCD, and the blood flow signal of the middle cerebral artery is detectable.;
* Signed informed consent by patient or their legally authorized representative.

Exclusion Criteria:

* Comorbid conditions with severe infections or severe diseases of the liver, kidney, hematopoietic system, endocrine system, etc.;
* Occurrence of intracranial hemorrhage (cerebral parenchymal hemorrhage, subarachnoid hemorrhage, subdural/epidural hemorrhage) within 90 days prior to enrollment;
* Severe hematological disorders or significant coagulation abnormalities;
* Pregnant or breastfeeding women;
* Participation in another clinical trial within the past 3 months or ongoing participation;
* Any other circumstances deemed by the investigator as unsuitable for participation in this clinical study.

Where it's running

• Department of Neurology, General Hospital of Northern Theater Command
  Shenyang, China Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.