Using tranexamic acid to treat traumatic bleeding with real-time monitoring

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of tranexamic acid (TXA) in patients with traumatic bleeding by utilizing dynamic monitoring of coagulation status through thromboelastography (TEG). The study aims to compare the traditional TXA administration regimen with a modified approach that allows for additional doses based on real-time monitoring. By assessing the coagulation and fibrinolytic status of trauma patients, the trial seeks to optimize TXA use to reduce mortality rates while minimizing thromboembolic risks. The study focuses on patients who have experienced severe trauma and are at high risk of bleeding complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. . trauma patients 18 -80 years of age (50 points \> trauma ISS score \> 16);
2. . hypotension (systolic blood pressure ≤ 90 mm Hg) and/or tachycardia (heart rate ≥ 110 beats/min);
3. . receiving a 1 g TXA push within 3 h of the injury, with the push completed within 10 min of arrival at the hospital.
4. . signing the informed consent form.

Exclusion Criteria:

1. .Coagulation abnormalities due to co-morbid hematologic or autoimmune diseases
2. Inability to establish venous or intraosseous access
3. Pregnant women
4. Traumatic cardiac arrest for more than 5 minutes
5. Failure of cardiopulmonary resuscitation
6. Penetrating brain injury
7. Drowning or hanging -

Where it's running

• Nanfang Hospital, Southern Medical University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Xu Li, doctor
• Email: mylx99@smu.edu.cn
• Phone: +86 18680248866

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Simplified Tranexamic Acid Regimen for Trauma with Hemorrhage

  This trial tests a simplified TXA dosing approach to see if it safely helps adults with major trauma and significant bleeding.

  Recruiting at 3 sites Phase 4 Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang and 2 other locations · NCT07869537

• Stability of blood clotting products in ambulances under real-world conditions

  This study checks whether fibrinogen concentrates and Octaplas plasma stay stable when stored in real EMS ambulances in Graz, Austria.

  Recruiting Medical University of Graz · Graz · NCT07646964

• Rapid bedside fibrinogen testing for bleeding trauma patients in the emergency department

  This will test a rapid bedside fibrinogen test for adults with traumatic bleeding to help decide who needs fibrinogen replacement.

  Recruiting Erasmus Medical Center · Rotterdam, South Holland · NCT07097337

• Using ROTEM analysis to improve outcomes in sepsis and trauma patients

  This study is testing if a special blood test can help doctors spot early signs of serious blood clotting issues in patients with sepsis or trauma to improve their treatment.

  Recruiting Region Stockholm · Stockholm · NCT06891599

• Empiric prehospital transfusion bundle for traumatic haemorrhagic shock

  We will try giving fibrinogen, plasma, and tranexamic acid before hospital arrival to adults with suspected life‑threatening bleeding from trauma to see if outcomes and safety change.

  Recruiting Medical University of Graz · Graz · NCT06891131

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.