Clinical trial Recruiting at 1 site Interventional Ages 20 to 90 Women only

Using tranexamic acid to reduce blood loss during vaginal hysterectomy

Official title: Local Tranexamic Acid During Vaginal Hysterectomy to Reduce Blood Loss

Run by Meir Medical Center · NCT04760301 · Data updated 2026-11-12

This study is testing if a local injection of tranexamic acid can help reduce blood loss during vaginal hysterectomy surgeries.

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Quick facts

Study typeInterventional
Ages20 Years to 90 Years
SexWomen only
Enrollment60 (estimated)
SponsorMeir Medical Center
Academic / other
Locations2 sites (Kfar Saba, Israel and 1 other locations)
StatusRecruiting
StartedFebruary 16, 2021
Main results expectedJuly 2025
Study endsJune 2026
Registry record updatedMay 6, 2025
Trial IDNCT04760301 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are female patients aged 20-90 who are scheduled for a vaginal hysterectomy.

Probably not a fit

Patients experiencing massive bleeding due to major vessel injury or those with known coagulopathies or sensitivity to tranexamic acid may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of local tranexamic acid in minimizing blood loss during vaginal hysterectomy procedures. Participants will be randomly assigned to receive either a local injection of tranexamic acid or a placebo (saline) at the start of the surgery. The study will measure the amount of blood loss during the operation to determine if tranexamic acid can significantly reduce bleeding. This approach could provide a simple and effective method to enhance surgical outcomes for patients undergoing this procedure.

Why it matters

Potential benefit: If successful, this treatment could lead to reduced blood loss during vaginal hysterectomies, improving patient safety and recovery.

How similar studies have gone: Other studies have shown promising results with the use of tranexamic acid in surgical settings, suggesting potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 20-90 years old female patients going through vaginal hysterctomy

Exclusion Criteria:

* massive bleeding during operation due to major vessles injury
* known coagulopathies
* sensitivity to tranexamic acid
* medical need in tranexamic acid administration during operation due to bleeding

Where it's running

  • Meir medical center
    Kfar Saba, Israel
    Recruiting
  • Meir Medical Center
    Kfar Saba, Israel, Israel
    Not yet recruiting

Study contacts

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.