Using tranexamic acid on surgical wounds to reduce complications
Official title: The Effect of Topical Tranexamic Acid on Postoperative Complications in Soft Tissue Plastic Surgery - A Multicenter Randomized Controlled Trial
Run by St. Olavs Hospital · NCT06270407 · Data updated 2026-11-12
This study is testing if applying tranexamic acid to surgical wounds can help reduce complications like bleeding and infections for people undergoing plastic surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 3000 (estimated) |
| Sponsor | St. Olavs Hospital Academic / other |
| Locations | 11 sites (Vejle and 10 other locations) |
| Status | Recruiting |
| Started | September 18, 2024 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2029 |
| Registry record updated | August 14, 2026 |
| Trial ID | NCT06270407 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults over 18 undergoing plastic surgical procedures that typically involve the use of topical TXA.
✕Probably not a fit
Patients with known allergies to tranexamic acid or those who cannot provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of applying tranexamic acid (TXA) directly onto surgical wounds in plastic surgery to determine if it can reduce postoperative complications such as re-bleeding, infections, and wound ruptures. Participants will receive either TXA or a placebo at the end of their surgery, with neither the patients nor the study personnel aware of which treatment is administered. The study will monitor complications for 30 days post-surgery through medical record reviews, electronic self-reporting, and follow-up calls. A total of 1500 patients will be enrolled in each group to assess the efficacy of TXA compared to placebo.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of postoperative complications in plastic surgery patients.
How similar studies have gone: Previous studies have shown promising results with the use of tranexamic acid in reducing surgical complications, suggesting this approach may be effective.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients are eligible to be included in the study only if all of the following criteria apply: 1. They are to undergo a surgical procedure within the field of plastic surgery where the procedure involves use of topical TXA at the participating center. 2. They are over 18 years of age and capable of independently providing informed consent 3. They have received adequate oral and written information about the study and signed the informed-consent form Exclusion Criteria: * Patients with known allergy to tranexamic acid.
Where it's running
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Vejle Sykehus
Vejle, Denmark Recruiting -
Helsinki University Hospital HUS
Helsinki, Finland Recruiting -
Haraldsplass Diakonale Sykehus
Bergen, Norway Recruiting -
Bærum Sykehus
Gjettum, Norway Recruiting -
Sykehuset Nordmøre og Romsdal
Hjelset, Norway Recruiting -
Oslo Universitetssykehus Rikshospitalet
Oslo, Norway Recruiting
Show 5 more locations
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UNN Tromsø
Tromsø, Norway Recruiting -
St Olav's University Hospital
Trondheim, Norway Recruiting -
Sykehuset Innlandet Tynset
Tynset, Norway Recruiting -
Sykehuset Innlandet Hamar
Hamar, Norway Not yet recruiting -
Stavanger Universitetssykehus SUS
Stavanger, Norway Not yet recruiting
Study contacts
- Principal investigator: Kjersti Ausen, MD PhD — St Olav's University Hospital
- Study coordinator: Kjersti Ausen, MD PhD
- Email: kjerstiausen@gmail.com
- Phone: +4792249693
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.