Using Trametinib to treat complicated vascular malformations
Phase II Clinical Trial of MEK Inhibitor Trametinib in the Treatment of Complicated Extracranial Arterial Venous Malformation (VM)
This study is testing if a pill called Trametinib can safely help children and adults with complicated blood vessel malformations feel better and reduce complications.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 12 Years to 60 Years |
| Sex | All |
| Sponsor | Stanford University Academic / other |
| Drugs / interventions | chemotherapy, radiation, Trametinib |
| Locations | 1 site (Palo Alto, California) |
| Trial ID | NCT04258046 on ClinicalTrials.gov |
What this trial studies
This study evaluates the safety and effectiveness of Trametinib, a medication taken in tablet form, for treating complicated extracranial arteriovenous malformations (AVMs) in both children and adults. AVMs are congenital vascular anomalies that can lead to severe complications, and current treatments often have high recurrence rates. The trial aims to provide a new therapeutic option for patients suffering from this condition. Participants will be monitored for their response to the treatment and any side effects experienced.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 12 to 60 years with a confirmed diagnosis of complicated extracranial AVMs.
Not a fit: Patients outside the age range of 12 to 60 years or those without a confirmed diagnosis of complicated AVMs may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly reduce complications and improve quality of life for patients with complicated AVMs.
How similar studies have performed: While there is limited data on the use of Trametinib for AVMs, similar approaches targeting the RAS/MAPK pathway have shown promise in other vascular conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient must be ≥ 12 years and ≤ 60 years * Confirmed diagnosis of complicated extracranial AVMs made by a physician who is familiar with this condition. * Genetic testing for mutations within MAP2K1 or remaining RAS/MAPK pathway is preferred but not mandatory * Patient is able to swallow and/or retain oral medication via G tube * All clinical and laboratory studies to determine eligibility will be performed within six weeks prior to enrollment unless otherwise indicated. * Patients who have undergone surgical resection or interventional radiology procedures (sclerotherapy) of their AVM are eligible if they meet all inclusion criteria after these procedures * At least 4 weeks from undergoing any major surgery * Patients with endocrine deficiencies are allowed to receive physiologic or stress doses of steroids if necessary. * Myelosuppressive chemotherapy: None within 4 weeks of entry into this study. * At least 14 days since the completion of therapy with a biologic. For agents that have known adverse events occurring beyond 14 days after administration, this period must be extended beyond the time during which adverse events are known to occur. These patients must be discussed among PI and other investigators on a case-by-case basis. * Patients must not have received an investigational drug within the prior 4 weeks. * Not within 6 months prior to entering study if AVM is within field of radiation Exclusion Criteria: * AVM due to germline mutation such as PTEN * Prior MEK inhibitor therapy or have allergy or contraindication to MEK inhibitor * Unable to swallow PO drugs or administer the drug via G tube * Patients who have undergone major surgery ≤ 4 weeks prior to starting study treatment or who have not recovered from side effects of such procedure * Patients with evidence of or history of cardiovascular risk * Patients with retinal vein occlusion, hemorrhage or have a history of such conditions. * Patients who are currently on other immunosuppressive medication(s) * Patients who have an uncontrolled infection * Unstable health status that may interfere with completing study * Unable to travel to clinic as requested * Patients unwilling or unable to comply with the protocol, or who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study. * Females of child-bearing potential must be willing to practice acceptable methods of birth control. * Additionally, females of childbearing potential must have a negative serum pregnancy test result from 7 days prior to the initiation of the medication to 3 months after the final administration of the medication. Males or females of reproductive potential may not participate unless they have agreed to use an effective contraceptive method during the period when they are receiving the study drug and for 3 months thereafter.
Where this trial is running
Palo Alto, California
- Pediatric Dermatology Clinic at Stanford Children's Hospital — Palo Alto, California, United States (Recruiting)
Study contacts
- Principal investigator: Joyce Teng, MD, PhD, FAAD — Stanford University
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.