Using topical medications to reduce redness from sunlight in rosacea patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial evaluates the effectiveness of topical imipramine and amitriptyline in reducing ultraviolet B light-induced redness in patients diagnosed with rosacea. The study aims to determine if these medications can alleviate the skin irritation and redness that often occurs in response to sunlight exposure. Participants will be monitored for their reactions to the treatments, comparing the effects of the active medications against a vehicle control. The trial focuses on individuals with specific skin types and a history of rosacea symptoms.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Fitzpatrick Skin Type I - IIII
* Self-identified rosacea or no history of flushing/blushing for controls
* Able to provide medical history and list of medications -- control subjects will not be allowed to take medications that are known to be photosensitizers.

Exclusion Criteria:

* Using imipramine, amitriptyline or any other tricyclic antidepressant (oral or topical)
* Using topical anti-inflammatory (within 1 week) or systemic agents (e.g. prednisone)
* Large tattoos in the designated testing areas
* Tanning bed use within last 3 months
* Photodynamic Therapy or UCB treatments in past 3 months
* Female Subjects: pregnant or nursing

Where it's running

• Wright State Physicians
  Fairborn, Ohio, United States Recruiting

Study contacts

• Study coordinator: Manager Clinical Research Operations
• Email: pturesearch@wrightstatephysicians.org
• Phone: (937)-245-7500

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.