Using topical adrenaline to reduce bleeding during cesarean delivery for placenta previa and accreta
Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bleeding During Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS): A Randomized Controlled Study
This study is testing if using topical adrenaline during cesarean deliveries can help pregnant women with placenta previa and accreta have less bleeding compared to using warm saline.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 84 (estimated) |
| Ages | 18 Years to 40 Years |
| Sex | Female |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06030479 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of topical adrenaline compared to warm saline solution in minimizing intraperitoneal bleeding during cesarean deliveries for patients diagnosed with placenta previa and placenta accreta spectrum. The study involves 84 pregnant women who are randomly assigned to receive either topical adrenaline or warm saline during their procedure. The aim is to determine if adrenaline can significantly reduce the risk of massive hemorrhage, which is a major complication associated with these conditions.
Who should consider this trial
Good fit: Ideal candidates for this study are pregnant women aged 18 to 40 with a diagnosis of placenta previa and placenta accreta spectrum who are vitally stable.
Not a fit: Patients who are vitally unstable or experiencing massive pre- or intra-operative bleeding will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce maternal morbidity and mortality associated with cesarean deliveries in patients with placenta previa and accreta.
How similar studies have performed: While the use of topical adrenaline has shown promise in other surgical contexts, this specific application in obstetrics is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 18 to 40 years. * BMI \< 35. * Pregnant patients with placenta previa . * Placenta accrete spectrum. * Vitally stable . Exclusion Criteria: * Vitally unstable . * Massive pre- or intra-operative bleeding. * Medical disorders ( e.g. : hypertension , cardiac .... )
Where this trial is running
Cairo
- Kasr Alainy outpatient clinic — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: bassiony dabian, MD
- Email: bassiony.dabian@gmail.com
- Phone: 1095195513
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.