Using Theta-Burst Transcranial Magnetic Stimulation to Treat Freezing of Gait
Effect of Theta-Burst Transcranial Magnetic Stimulation (TBS) for Freezing of Gait
This study is testing if a new brain stimulation treatment can help people with freezing of gait improve their walking and movement.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 40 Years to 85 Years |
| Sex | All |
| Sponsor | Anhui Medical University Academic / other |
| Locations | 1 site (Hefei, Anhui) |
| Trial ID | NCT05192759 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of Theta-burst Transcranial Magnetic Stimulation (TBS) on patients experiencing freezing of gait (FOG). Forty patients diagnosed with FOG will undergo TBS treatment for one week, with assessments conducted before and after the treatment to evaluate changes in symptoms and underlying neural mechanisms. Various cognitive and motor tests, along with MRI and EEG, will be utilized to gather comprehensive data on the efficacy of the treatment. Follow-up evaluations will occur one and two months post-treatment to monitor ongoing effects.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 40 and older who have been diagnosed with freezing of gait and are on stable medication.
Not a fit: Patients with a history of psychiatric disorders, neurological diseases other than Parkinson's disease, or those who have previously received rTMS treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could significantly improve mobility and quality of life for patients suffering from freezing of gait.
How similar studies have performed: While the use of TBS is a novel approach in this context, similar studies have shown promise in using transcranial magnetic stimulation for various neurological conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. diagnosis of FOG with expertise in movement disorders. 2. the score of item 3 of the FOG questionnaire ≥1. 3. ongoing treatment with a stable dose of any medication for 2 months. 4. 40 years of age or older. Exclusion Criteria: 1. a history of addiction, psychiatric disorders, or neurological diseases other than PD. 2. focal brain lesions on T1-/T2-weighted fluid-attenuated inversion recovery images. 3. anti-PD medication adjustments during rTMS treatment. 4. history of substance abuse within the past 6 months. 5. nonremovable metal objects in or around the head. 6. previously received rTMS treatment. 7. prior history of seizure or history in first-degree relatives.
Where this trial is running
Hefei, Anhui
- Cognitive Neuropsychology Lab Anhui Medical University — Hefei, Anhui, China (Recruiting)
Study contacts
- Study coordinator: Gong-Jun JI, Ph.D.
- Email: jigongjun@163.com
- Phone: +8655162923704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.