Using Theta-Burst Transcranial Magnetic Stimulation to Treat Freezing of Gait

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of Theta-burst Transcranial Magnetic Stimulation (TBS) on patients experiencing freezing of gait (FOG). Forty patients diagnosed with FOG will undergo TBS treatment for one week, with assessments conducted before and after the treatment to evaluate changes in symptoms and underlying neural mechanisms. Various cognitive and motor tests, along with MRI and EEG, will be utilized to gather comprehensive data on the efficacy of the treatment. Follow-up evaluations will occur one and two months post-treatment to monitor ongoing effects.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. diagnosis of FOG with expertise in movement disorders.
2. the score of item 3 of the FOG questionnaire ≥1.
3. ongoing treatment with a stable dose of any medication for 2 months.
4. 40 years of age or older.

Exclusion Criteria:

1. a history of addiction, psychiatric disorders, or neurological diseases other than PD.
2. focal brain lesions on T1-/T2-weighted fluid-attenuated inversion recovery images.
3. anti-PD medication adjustments during rTMS treatment.
4. history of substance abuse within the past 6 months.
5. nonremovable metal objects in or around the head.
6. previously received rTMS treatment.
7. prior history of seizure or history in first-degree relatives.

Where it's running

• Cognitive Neuropsychology Lab Anhui Medical University
  Hefei, Anhui, China Recruiting

Study contacts

• Study coordinator: Gong-Jun JI, Ph.D.
• Email: jigongjun@163.com
• Phone: +8655162923704

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Decoding brain signals and DBS settings for freezing of gait in Parkinson’s

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• Comparing cervical versus thoracic trans‑spinal magnetic stimulation added to brain TMS to improve walking in Parkinson's disease

  This trial will test whether adding cervical or thoracic trans‑spinal magnetic stimulation to repetitive brain TMS helps people with Parkinson's and gait problems walk better and move more easily.

  Recruiting Universidade Federal de Pernambuco · Recife, Pernambuco · NCT07488026

• Causes and outcomes of freezing of gait in Parkinsonian conditions

  This registry will collect long-term clinical, gait, and video data from adults with freezing of gait or related parkinsonian conditions to see if different causes lead to distinct symptoms, walking patterns, falls, and disease progression.

  Recruiting Tianjin Huanhu Hospital · Tianjin, Tianjin Municipality · NCT07386015

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.