Using the perfusion index to monitor children during low-flow anesthesia
Official title: Changes in Perfusion Index Under Low-Flow Anesthesia and Its Effects on Postoperative Emergence in Pediatric Patients
Run by Istinye University · NCT06967675 · Data updated 2026-11-12
This project tests whether tracking the perfusion index during low-flow versus normal-flow anesthesia can help predict blood flow stability and emergence agitation in children aged 2 to 12 having elective surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 2 Years to 12 Years |
| Sex | All |
| Enrollment | 90 (estimated) |
| Sponsor | Istinye University Academic / other |
| Locations | 1 site (Istanbul, Merkez Mahallesi) |
| Status | Recruiting |
| Started | June 15, 2025 |
| Main results expected | August 5, 2025 |
| Study ends | August 10, 2025 |
| Registry record updated | July 10, 2025 |
| Trial ID | NCT06967675 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are ASA I–II children aged 2–12 years having elective surgeries lasting 1–6 hours whose parents or guardians provide consent and who have no major cardiopulmonary, neurologic, metabolic, or developmental disorders.
✕Probably not a fit
Children with significant cardiovascular, respiratory, or neurodevelopmental disorders, those requiring emergency surgery or inhalational induction, or operations needing high gas flows or lasting over six hours are excluded and unlikely to benefit from these findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is an observational interventional-arm comparison in which pediatric patients undergoing elective surgery under routine care are assigned to low-flow or normal-flow anesthesia groups. The perfusion index (PI) will be recorded at multiple intraoperative and postoperative time points alongside hemodynamic measures and depth-of-anesthesia markers. The study will compare PI trajectories between groups and examine whether PI changes are linked to hemodynamic stability and the occurrence of emergence agitation. No additional interventions beyond standard clinical care will be applied.
Why it matters
Potential benefit: If successful, clinicians could use perfusion index monitoring to better predict recovery patterns and reduce emergence agitation after pediatric low-flow anesthesia.
How similar studies have gone: Prior adult and some pediatric studies have found correlations between perfusion index and peripheral perfusion or anesthesia depth, but results are mixed and its ability to predict emergence agitation is still limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA I-II pediatric patients * Age 2 to 12 years * Undergoing elective surgery lasting between 1-6 hours * Informed consent obtained from parents/guardians Exclusion Criteria: * Cardiovascular, respiratory, neurological, metabolic, or endocrine disorders * Premature birth with corrected age \< 2 years * Obesity or severe malnutrition (BMI \<5th or \>95th percentile) * Psychiatric or neurodevelopmental disorders (e.g., autism) * Malignant hyperthermia or hypersensitivity to anesthetics * Emergency surgeries * Lack of IV access requiring inhalational induction * Contraindications to low-flow anesthesia including: * Severe pulmonary disease * Congenital heart disease with shunt physiology * Anticipated high oxygen demand * Airway obstruction risk * Surgeries requiring high gas flow or \>6 hours duration
Where it's running
-
Istinye Üniversity
Istanbul, Merkez Mahallesi, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: ilke dolgun
- Email: ilkeser2004@gmail.com
- Phone: +905555485632
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.