Using the Naples Prognostic Score to predict delirium after hip surgery
Naples Prognostic Score for Predicting Postoperative Delirium in the Elderly Undergoing Hip Fracture Surgeries
This project will test whether the Naples Prognostic Score (from routine preoperative blood tests) can help predict postoperative delirium in people aged 60 and older having hip fracture surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 168 (estimated) |
| Ages | 60 Years and up |
| Sex | All |
| Sponsor | South Valley University Academic / other |
| Locations | 1 site (Qina, Qena Governorate) |
| Trial ID | NCT07297017 on ClinicalTrials.gov |
What this trial studies
This observational study will calculate the Naples Prognostic Score (NPS) from routine preoperative blood markers—albumin, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio—in patients aged 60 and older undergoing hip fracture surgery. Researchers will follow patients through the postoperative period to record who develops postoperative delirium and compare NPS values between those who do and do not develop delirium. Patients with preexisting dementia, mild cognitive impairment, or active infections are excluded to focus on new-onset postoperative delirium. The goal is to determine whether a simple, blood-based score measured before surgery correlates with delirium risk in this geriatric surgical population.
Who should consider this trial
Good fit: Ideal candidates are patients aged 60 or older with hip fracture who are ASA class II–IV, have preoperative blood samples available, do not have dementia or active infection, and can give consent at Qena University.
Not a fit: Patients with preexisting dementia or mild cognitive impairment, active preoperative infections, or those not undergoing hip fracture surgery are unlikely to benefit from these findings.
Why it matters
Potential benefit: If successful, clinicians could use a simple preoperative blood-based score to identify older hip surgery patients at higher risk of delirium and target prevention or monitoring.
How similar studies have performed: The NPS was originally used in oncology and inflammatory conditions and its components (albumin, NLR, LMR) have been linked to delirium risk, but applying the complete NPS to predict postoperative delirium is relatively novel with limited prior validation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * The elderly age≥60 years * American Society of Anesthesiologists (ASA) classification II∼IV * Patients undergoing hip fracture surgery * Patients who had a complete blood sample were taken preoperatively Exclusion Criteria: * Patient refused to participate and consent * Patients with a history of mild cognitive impairment (MCI), dementia, and delirium * Ptients with known preoperative infections (pulmonary infection, urinary infection, and sepsis).
Where this trial is running
Qina, Qena Governorate
- Qena University — Qina, Qena Governorate, Egypt (Recruiting)
Study contacts
- Study coordinator: Zeinab M Sayed, MD
- Email: zeinab5aton@gmail.com
- Phone: +201009071365
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.