Using the Naples Prognostic Score to predict delirium after hip surgery
Official title: Naples Prognostic Score for Predicting Postoperative Delirium in the Elderly Undergoing Hip Fracture Surgeries
Run by South Valley University · NCT07297017 · Data updated 2026-11-12
This project will test whether the Naples Prognostic Score (from routine preoperative blood tests) can help predict postoperative delirium in people aged 60 and older having hip fracture surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 60 Years and up |
| Sex | All |
| Enrollment | 168 (estimated) |
| Sponsor | South Valley University Academic / other |
| Locations | 1 site (Qina, Qena Governorate) |
| Status | Recruiting |
| Started | January 10, 2026 |
| Main results expected | June 2027 |
| Study ends | December 2027 |
| Registry record updated | May 14, 2026 |
| Trial ID | NCT07297017 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients aged 60 or older with hip fracture who are ASA class II–IV, have preoperative blood samples available, do not have dementia or active infection, and can give consent at Qena University.
✕Probably not a fit
Patients with preexisting dementia or mild cognitive impairment, active preoperative infections, or those not undergoing hip fracture surgery are unlikely to benefit from these findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study will calculate the Naples Prognostic Score (NPS) from routine preoperative blood markers—albumin, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio—in patients aged 60 and older undergoing hip fracture surgery. Researchers will follow patients through the postoperative period to record who develops postoperative delirium and compare NPS values between those who do and do not develop delirium. Patients with preexisting dementia, mild cognitive impairment, or active infections are excluded to focus on new-onset postoperative delirium. The goal is to determine whether a simple, blood-based score measured before surgery correlates with delirium risk in this geriatric surgical population.
Why it matters
Potential benefit: If successful, clinicians could use a simple preoperative blood-based score to identify older hip surgery patients at higher risk of delirium and target prevention or monitoring.
How similar studies have gone: The NPS was originally used in oncology and inflammatory conditions and its components (albumin, NLR, LMR) have been linked to delirium risk, but applying the complete NPS to predict postoperative delirium is relatively novel with limited prior validation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * The elderly age≥60 years * American Society of Anesthesiologists (ASA) classification II∼IV * Patients undergoing hip fracture surgery * Patients who had a complete blood sample were taken preoperatively Exclusion Criteria: * Patient refused to participate and consent * Patients with a history of mild cognitive impairment (MCI), dementia, and delirium * Ptients with known preoperative infections (pulmonary infection, urinary infection, and sepsis).
Where it's running
-
Qena University
Qina, Qena Governorate, Egypt Recruiting
Study contacts
- Study coordinator: Zeinab M Sayed, MD
- Email: zeinab5aton@gmail.com
- Phone: +201009071365
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.