Using Terahertz Scanning to Evaluate Corneal Scars and Edema
Official title: Validation of the Use of Terahertz Scanning System on Corneal Scars and Corneal Edema: Phase II Clinical Trial
Run by Singapore Eye Research Institute · NCT06983652 · Data updated 2026-11-12
This study is testing a new scanning technology to see if it can better measure corneal scars and swelling in people with these eye conditions.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 21 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Singapore Eye Research Institute Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Singapore) |
| Status | Recruiting |
| Started | July 1, 2024 |
| Main results expected | June 30, 2026 |
| Study ends | August 31, 2026 |
| Registry record updated | May 21, 2025 |
| Trial ID | NCT06983652 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals aged 21 and older with corneal endothelial dysfunction or corneal scars without corneal edema.
✕Probably not a fit
Patients with active inflammation or infection in the eyes, or those unable to comply with study requirements, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to validate the effectiveness of a Terahertz (THz) scanning system in assessing corneal edema and scars. Participants with these conditions will undergo THz scanning, followed by conventional clinical examinations to characterize their corneal lesions. The study will evaluate the correlation between THz scan measurements and standard clinical methods, hypothesizing that THz scanning can accurately assess corneal hydration levels. This innovative approach seeks to provide a quantitative tool for monitoring disease progression and aiding surgical decisions.
Why it matters
Potential benefit: If successful, this study could lead to improved monitoring and management of corneal diseases, potentially reducing the need for invasive procedures.
How similar studies have gone: While the use of THz scanning in other medical fields has shown promise, this specific application in corneal assessment is relatively novel and untested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Be at least 21 years of age. * Regardless of gender (Male/Female). * Regardless of race (Chinese/Malay/Indian/Eurasian/Others). * Willingness and ability to follow all instructions and comply with study schedule for study visit. * Patients with corneal endothelial dysfunction (Fuchs' endothelial dystrophy or other causes of bullous keratopathy) at any disease stage OR Patients with corneal scars from any cause, with the absence of corneal edema. * Ability to hold face sufficiently stable to undergo necessary scans. Exclusion Criteria: * Eyes with active inflammation or infection, or chronic ocular surface inflammation * Unable to give consent * Physically immobile/poor instructional compliance * PI determined * Pregnant/ breast feeding women
Where it's running
-
Singapore National Eye Centre
Singapore, Singapore Recruiting
Study contacts
- Study coordinator: Yu-Chi Liu, MD, MCI, PhD
- Email: liu.yu.chi@snec.com.sg
- Phone: 65 65767287
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.