Using tDCS to reduce loneliness in older adults with depression
Effects of Transcranial Direct Current Stimulation on Loneliness in Older Adults With Depression: A Randomized Controlled Trial
This study is testing if a brain stimulation technique can help reduce feelings of loneliness in older adults who are dealing with depression.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 60 Years to 80 Years |
| Sex | All |
| Sponsor | Guangzhou Psychiatric Hospital Government |
| Locations | 1 site (Guangzhou, Guangdong) |
| Trial ID | NCT06658795 on ClinicalTrials.gov |
What this trial studies
This trial investigates the effects of transcranial direct current stimulation (tDCS) on loneliness levels in older adults diagnosed with major depressive disorder. It aims to evaluate how repeated sessions of tDCS can influence feelings of loneliness, which are prevalent in this population and linked to poor recovery rates from depression. The study compares the effects of tDCS applied to different brain regions against a sham stimulation group to understand its potential benefits. By targeting specific neural networks associated with loneliness, the trial seeks to enhance emotional regulation and social connectivity among participants.
Who should consider this trial
Good fit: Ideal candidates are older adults with major depressive disorder who experience high levels of loneliness.
Not a fit: Patients with severe neurological diseases, bipolar disorder, schizophrenia, or those with suicidal ideation may not benefit from this study.
Why it matters
Potential benefit: If successful, this intervention could significantly improve emotional well-being and social connections in older adults suffering from depression and loneliness.
How similar studies have performed: Previous studies have shown promise in using tDCS for emotional regulation, suggesting potential success for this approach in alleviating loneliness.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * High loneliness (UCLA Loneliness Scale \> 43). * Diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-5 Disorders. * absence of suicidal ideation (Hamilton Depression Scale item 3 score ≤ 1). Exclusion Criteria: * Severe neurological diseases. * Bipolar disorder, schizophrenia, addiction, or impulse control disorders. * Contraindications for tDCS or MRI (e.g., metal implants). * Presence of suicidal ideation.
Where this trial is running
Guangzhou, Guangdong
- Guangzhou Brain Hospital — Guangzhou, Guangdong, China (Recruiting)
Study contacts
- Study coordinator: Kangguang Lin, PhD; MD
- Email: klin@gzhmu.edu.cn
- Phone: 8613560360144
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.