Using tDCS to reduce loneliness in older adults with depression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This trial investigates the effects of transcranial direct current stimulation (tDCS) on loneliness levels in older adults diagnosed with major depressive disorder. It aims to evaluate how repeated sessions of tDCS can influence feelings of loneliness, which are prevalent in this population and linked to poor recovery rates from depression. The study compares the effects of tDCS applied to different brain regions against a sham stimulation group to understand its potential benefits. By targeting specific neural networks associated with loneliness, the trial seeks to enhance emotional regulation and social connectivity among participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* High loneliness (UCLA Loneliness Scale \> 43).
* Diagnosis of major depressive disorder confirmed by the Structured Clinical Interview for DSM-5 Disorders.
* absence of suicidal ideation (Hamilton Depression Scale item 3 score ≤ 1).

Exclusion Criteria:

* Severe neurological diseases.
* Bipolar disorder, schizophrenia, addiction, or impulse control disorders.
* Contraindications for tDCS or MRI (e.g., metal implants).
* Presence of suicidal ideation.

Where it's running

• Guangzhou Brain Hospital
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Kangguang Lin, PhD; MD
• Email: klin@gzhmu.edu.cn
• Phone: 8613560360144

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.