Using targeted brain stimulation to improve upper limb movement after stroke
Determine the Effect of Targeted High-definition tDCS on Reducing Post-stroke Upper Limb Motor Impairments
NA · Carle Foundation Hospital · NCT05479006
This study tests whether a special type of brain stimulation can help improve arm movement in people who have had a stroke.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 90 Years |
| Sex | All |
| Sponsor | Carle Foundation Hospital (other) |
| Locations | 1 site (Urbana, Illinois) |
| Trial ID | NCT05479006 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of targeted high-definition transcranial direct current stimulation (tDCS) on reducing motor impairments in the upper limb following a stroke. Participants will undergo a series of interventions involving different stimulation techniques, including anodal and cathodal stimulation, in a randomized and double-blinded manner. The study aims to assess the impact of these interventions on motor function by utilizing a subject-specific head model to optimize stimulation parameters. The total duration of participation is approximately 10 weeks, including four intervention visits and assessments.
Who should consider this trial
Good fit: Ideal candidates are individuals with substantial motor impairment of one upper limb due to a stroke.
Not a fit: Patients with severe cognitive dysfunction, significant sensory deficits, or other severe medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance motor recovery in stroke patients, improving their quality of life.
How similar studies have performed: Previous studies have shown promise in using non-invasive brain stimulation techniques for motor recovery in stroke patients, indicating potential for success in this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Paresis confined to one side, with substantial motor impairment of the paretic upper limb * Capacity to provide informed consent Exclusion Criteria: * Muscle tone abnormalities and motor or sensory impairment in the non-paretic limb * Severe wasting or contracture or significant sensory deficits in the paretic upper limb * Severe cognitive or affective dysfunction that prevents normal communication and understanding of consent or instruction * Severe concurrent medical problems (e.g. cardiorespiratory impairment) * Using a pacemaker * Metal implants in the head * Known adverse reactions to TMS and tDCS * Pregnant
Where this trial is running
Urbana, Illinois
- Carle Foundation Hospital — Urbana, Illinois, United States (RECRUITING)
Study contacts
- Study coordinator: Yuan Yang, PhD
- Email: yuan.yang@carle.com
- Phone: 217-244-5870
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Stroke, Non-invasive Brain Stimulation, Movement Impairment