Clinical trial Recruiting at 4 sites Early Phase 1 Interventional Ages 55 and up Men only

Using Tamsulosin to Reduce Urinary Retention After Thoracic Surgery

Official title: Post Operative Urinary Retention (POUR) Following Thoracic Oncological Surgery

Run by Hackensack Meridian Health · NCT05657990 · Data updated 2026-11-12

This study is testing if taking Tamsulosin for a week before thoracic surgery can help older men avoid problems with urination afterwards.

Quick facts

PhaseEarly Phase 1
Study typeInterventional
Ages55 Years and up
SexMen only
Enrollment46 (estimated)
SponsorHackensack Meridian Health
Academic / other
Locations4 sites (Brick, New Jersey and 3 other locations)
StatusRecruiting
StartedApril 3, 2023
Main results expectedJune 2027
Study endsJune 2027
Registry record updatedSeptember 9, 2026
Trial IDNCT05657990 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are males aged 55 and older scheduled for thoracic oncological surgery.

Probably not a fit

Patients currently using Tamsulosin or those with certain medical conditions such as hypotension or heart failure may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This feasibility study investigates whether Tamsulosin can reduce the incidence of postoperative urinary retention (POUR) in older men undergoing thoracic oncological surgery. The study focuses on men aged 55 and older who are scheduled for surgery and will take Tamsulosin for seven days prior to the procedure. Researchers will measure spontaneous voids and assess residual urine post-surgery to evaluate the effectiveness of the treatment. The goal is to determine if Tamsulosin can improve urinary function and reduce complications associated with POUR.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of urinary retention and related complications in older men after thoracic surgery.

How similar studies have gone: Previous studies have indicated that Tamsulosin may effectively reduce urinary retention, suggesting potential success for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Males
* ≥55 years old
* Planned thoracic oncological surgical procedure of a video assisted oncological surgical procedure for suspected or confirmed cancer.
* Surgery scheduled more than 7 days from the time of consent

Exclusion Criteria:

* Using Tamsulosin already
* Known allergy to Tamsulosin or sulfa drugs
* Current use of Boceprevir
* Resting systolic blood pressure \<100
* Orthostatic hypotension of \>20mm Hg systolic and/or 10mm Hg diastolic pressure from sitting to standing (after 2 minutes of standing) as measured at the time of consent
* Known history of hypotension
* Known diagnosis of congestive heart failure (CHF) and valvular heart disease
* History of prior prostate surgery (prostatectomy, trans-urethral resection)

Where it's running

  • Ocean University Medical Center
    Brick, New Jersey, United States
    Recruiting
  • South Ocean University Medical Center
    Manahawkin, New Jersey, United States
    Recruiting
  • Jersey Shore University Medical Center
    Neptune City, New Jersey, United States
    Recruiting
  • Riverview Medical Center
    Red Bank, New Jersey, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.