Using Sticky Bone and Bio-Oss Collagen to Preserve Alveolar Ridge After Tooth Extraction
Application of Sticky Bone and Bio-Oss Collagen in Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
This study is testing if using Sticky Bone or Bio-Oss Collagen after tooth extraction can help keep the jawbone strong and healthy for future dental implants.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 30 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Hangzhou, Zhejiang) |
| Trial ID | NCT05902689 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of two methods for preserving the alveolar ridge after tooth extraction: one using Bio-Oss Collagen and the other using Sticky Bone. Participants will be divided into three groups: a blank group that undergoes natural healing, a control group that receives Bio-Oss Collagen, and an experimental group that receives Sticky Bone. The goal is to assess how these interventions can maintain the volume of the alveolar socket, prevent undesirable soft tissue growth, and promote new bone formation, which is essential for future dental implants. The study will monitor changes in the alveolar ridge over a six-month period following tooth extraction.
Who should consider this trial
Good fit: Ideal candidates include individuals requiring tooth extraction with adequate oral hygiene and specific conditions at the extraction site.
Not a fit: Patients with uncontrolled periodontal disease, active infections, or significant systemic health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve outcomes for patients needing dental implants by preserving the alveolar ridge structure.
How similar studies have performed: Previous studies have shown promising results with similar alveolar ridge preservation techniques, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. The presence of one adjacent tooth at the extraction site 2. Adequate oral hygiene (plaque index \<20%;bleeding on probing \<25% ) 3. Need for tooth extraction due to endodontic，periapical or periodontal disease. 4. Presence of ≥ 2 mm of keratinized tissue 5. the extraction sockets have no more than 50% of buccal alveolar bone loss(Integrity of alveolar bone walls) Exclusion Criteria: 1. Pregnancy or lactation 2. Smoking more than 10 cigarettes per day 3. with no evidence of acute infection such as severe swelling, suppuration at the extraction site 4. Uncontrolled periodontal disease 5. Existence of bone metabolic disease 6. history of malignancy, radiotherapy, or chemotherapy in the past 5 years 7. Administration of bisphosphonates 8. long-term use of NSAIDs 9. Alcohol or drug abuse 10. Infectious disease, such as hepatitis or human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome (AIDS) 11. Uncontrolled severe diabetes.( hemoglobin A1c \>6.7%)
Where this trial is running
Hangzhou, Zhejiang
- 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Study coordinator: Li Li Zhou, doctor
- Email: sophiazhou04@163.com
- Phone: 18329193003
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.