Using St. John's Wort to treat recurrent mouth ulcers
Comparative Evaluation of the Effect of Hypericum Perforatum on Pain Level in the Treatment of Recurrent Aphthous Stomatitis:A Randomized Clinical Trial
This study is testing if St. John's Wort can help people with painful mouth ulcers feel better and heal faster compared to other treatments.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 75 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Batman University Academic / other |
| Locations | 1 site (Batman, Centre/Batman) |
| Trial ID | NCT06839313 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of St. John's Wort extract in treating Recurrent Aphthous Stomatitis (RAS), a condition characterized by painful mouth ulcers. The research compares the pain management and ulcer healing effects of St. John's Wort with those of triamcinolone acetonide and hyaluronic acid gel. Participants will be assessed for their clinical symptoms and the rate of ulcer healing over the course of the treatment. The study aims to provide a potential alternative for patients suffering from RAS, which currently lacks a definitive treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and over with a history of recurrent mouth ulcers for at least two years.
Not a fit: Patients with allergies to the treatment substances or those who are pregnant or lactating may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could offer a new, effective treatment option for patients suffering from recurrent mouth ulcers.
How similar studies have performed: While there is existing literature on the use of St. John's Wort for wound healing, this specific application for RAS is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. 18 years and over 2. Having a history of RAS for at least 2 years 3. Having one in an easily accessible area in the mouth 4. RAS has not exceeded a period of 48 hours Exclusion Criteria: 1. Having any allergic history to these substances to be applied 2. During pregnancy and lactation 3. Use of steroids, vitamins, antibiotics, antihistamines, oral retinoids or immune system regulating agents for ulcer treatment within 3 months 4. The patient has a history of systemic disease
Where this trial is running
Batman, Centre/Batman
- Batman University — Batman, Centre/Batman, Turkey (Türkiye) (Recruiting)
Study contacts
- Principal investigator: Rojdan F GÜNEŞ UYSAL, PhD — Batman University
- Study coordinator: Rojdan F GÜNEŞ UYSAL, PhD
- Email: rojdangunes@hotmail.com
- Phone: 05433796751
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.