Using spinal cord stimulation to treat symptoms of Parkinsonism
Official title: Spinal Cord Stimulation for Parkinsonism: a Single-center, Single-arm Open Trial
Run by Ruijin Hospital · NCT05171205 · Data updated 2026-11-12
This study is testing if spinal cord stimulation can help improve symptoms like low blood pressure, urinary issues, sleep problems, and speech difficulties in people with Parkinsonism.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 80 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Ruijin Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | May 1, 2021 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | May 9, 2025 |
| Trial ID | NCT05171205 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals aged 50 to 80 who have been diagnosed with Parkinsonism and can comply with study instructions.
✕Probably not a fit
Patients with severe depression, anxiety, or other non-neurological conditions that hinder participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial evaluates the effectiveness of spinal cord stimulation (SCS) as a treatment for various symptoms associated with Parkinsonism, including orthostatic hypotension, urinary retention, sleep disturbances, dysarthria, and dysphagia. The study will be conducted at a single center and aims to assess patient improvements before and after SCS treatment. By leveraging the established safety and reversibility of SCS, this innovative approach seeks to provide new therapeutic options for patients suffering from Parkinsonism.
Why it matters
Potential benefit: If successful, this treatment could significantly improve the quality of life for patients with Parkinsonism by alleviating debilitating symptoms.
How similar studies have gone: While spinal cord stimulation has been successfully used for chronic pain management, this specific application for Parkinsonism is novel and has not been extensively tested in prior studies.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion criteria: 1. Diagnosed with parkinsonism according to MDS clinical diagnostic criteria for Parkinson's disease 2. Aged between 50 and 80 years 3. Able and willing to follow instruction of the researcher 4. No other conditions that the researchers consider inappropriate for inclusion Exclusion criteria: 1. Severe depression (HAMD-17 above 17 as moderate to severe) or anxiety 2. Pregnancy 3. History of alcoholism 4. Non-neurological disease-related symptoms that prevent patients from participation in the study
Where it's running
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Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Principal investigator: Jun Liu, MD,PhD — Ruijin Hospital
- Study coordinator: Jun Liu, MD,PhD
- Email: jly0520@hotmail.com
- Phone: 021-64370045
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.