Using spinal cord stimulation to improve breathing during surgery
Official title: Recording of Intraoperative Spinal Cord Stimulation and Monitoring
Run by University of California, Los Angeles · NCT05356286 · Data updated 2026-11-12
This study is testing if a special electrical stimulation can help improve breathing in patients having brain or spinal cord surgery and reduce breathing problems caused by pain medications.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of California, Los Angeles Academic / other |
| Locations | 1 site (Los Angeles, California) |
| Status | Recruiting |
| Started | January 21, 2011 |
| Main results expected | January 22, 2027 |
| Study ends | January 22, 2027 |
| Registry record updated | March 10, 2025 |
| Trial ID | NCT05356286 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients undergoing brain or spinal cord surgery where spinal neuromonitoring is utilized.
✕Probably not a fit
Patients not undergoing any form of brain or spinal cord surgery will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of epidural electrical stimulation (EES) on respiratory function in patients undergoing brain or spinal cord surgery. The hypothesis is that EES at the cervical spinal cord can counteract opioid-induced respiratory depression, a serious complication that can occur during surgery. By monitoring respiratory function during the stimulation, researchers aim to gather data on its efficacy and safety in a clinical setting. The study will include patients who require spinal neuromonitoring, allowing for a focused examination of this intervention's potential benefits.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of respiratory depression in patients receiving opioids during surgery.
How similar studies have gone: While the specific application of EES for opioid-induced respiratory depression is novel, similar approaches in spinal cord stimulation have shown promise in other contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any patients undergoing brain or spinal cord surgery where spinal neuromonitoring is utilized. Exclusion Criteria: * none
Where it's running
-
University of California, Los Angeles
Los Angeles, California, United States Recruiting
Study contacts
- Study coordinator: Daniel Lu, MD
- Email: dclu@mednet.ucla.edu
- Phone: 310/825/4321
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.