Using sperm from micro-TESE to fertilize frozen oocytes
The Potential of Sperm Retrieved by Micro-TESE to Fertilize Vitrified/Warmed Oocytes
Odense University Hospital · NCT03809026
This study tests if using sperm from men who have trouble producing sperm can successfully fertilize frozen eggs for couples trying to conceive.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 100 Years |
| Sex | Male |
| Sponsor | Odense University Hospital (other) |
| Locations | 2 sites (Odense and 1 other locations) |
| Trial ID | NCT03809026 on ClinicalTrials.gov |
What this trial studies
This observational study involves couples who are referred for microdissection-TESE (m-TESE) due to conditions like Klinefelter's syndrome or failed sperm retrieval. Women in the study undergo ovarian stimulation with FSH as part of IVF protocols, and their aspirated oocytes are vitrified. The study compares fertilization, cleavage, implantation, and pregnancy rates using sperm retrieved from patients via micro-TESE against those using donor sperm. The goal is to assess the effectiveness of using patient-derived sperm for fertilization of warmed oocytes.
Who should consider this trial
Good fit: Ideal candidates for this study are couples experiencing nonobstructive azoospermia who are referred for micro-TESE.
Not a fit: Patients who have obstructive azoospermia or those who do not require sperm retrieval may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide a viable option for couples facing infertility due to azoospermia.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in using micro-TESE sperm for fertility treatments.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Couples referred for micro-TESE Exclusion Criteria: None
Where this trial is running
Odense and 1 other locations
- Centre of Andrology & Fertility Clinic, Department D, Odense University Hospital — Odense, Denmark (RECRUITING)
- Centre of Andrology & Fertility Clinic, Odense University Hospital — Odense, Denmark (RECRUITING)
Study contacts
- Study coordinator: Jens Fedder, MD, PhD
- Email: fedder@dadlnet.dk
- Phone: +45 26820368
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Azoospermia, Nonobstructive, Azoospermia, micro-TESE, Klinefelter's syndrome, Cryptorchidism, Vitrified oocytes