Using special MRI to detect inflammation in brain tumors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the use of ultrasmall superparamagnetic iron oxide (USPIO) enhanced magnetic resonance imaging (MRI) to measure the abundance of tumor-associated macrophages in central nervous system tumors, specifically vestibular schwannomas and gliomas. By injecting USPIO into patients, the imaging technique aims to visualize and quantify the inflammatory response within the tumor, which may have implications for prognosis and treatment. The study focuses on determining the feasibility and effectiveness of this imaging method in a clinical setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Be at least 16 years old
* Have a CNS tumour suspected to be one of the defined histological types (vestibular scwhannoma or low grade glioma)
* Be able to lie still for up to 1 hour comfortably
* Opinion of the treating clinician is that the patient will be able to successfully complete the research imaging protocol.

Exclusion Criteria:

* Life expectancy less than 1 year
* Previous CNS radiotherapy/ stereotactic radiosurgery (SRS)
* Females who are pregnant/ breastfeeding
* Patients with an eGFR \< 30ml/min
* Patients with known and documented history of iron overload/haemosiderosis/ haemochromatosis
* Patients with immune or inflammatory conditions e.g. systemic lupus erythematous, rheumatoid arthritis
* Patients with absolute (e.g. pacemaker) and relative (anxiety or claustrophobia) contraindications to MR scanning
* Patients with a history of allergic reaction to iron or dextran
* Patients with a history of allergic reaction to gadolinium contrast agents, asthma or renal problems
* Patients who are unable to adequately understand verbal explanations or written information given in English.

Where it's running

• Salford Royal Hospital Northern Care Alliance NHS Foundation Trust
  Salford, Greater Manchester, United Kingdom Recruiting

Study contacts

• Principal investigator: David Coope, PhD FRCS(SN) — Northern Care Alliance NHS Foundation Trust
• Study coordinator: Daniel Lewis, PhD MBBS
• Email: daniel.lewis-3@manchester.ac.uk
• Phone: +441612067050

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• 3D MRI Elastography to Peek at Vestibular Schwannoma Stiffness and How It Relates to Surgery

  This study tests whether 3D MRI elastography can noninvasively measure how stiff vestibular schwannomas are and how firmly they stick to nearby tissues, to help predict surgical difficulty and outcomes.

  Recruiting Shengjing Hospital · Shenyang, Liaoning · NCT07844460

• Vestibular rehabilitation for adults having surgery for a unilateral vestibular schwannoma

  This trial tests whether home-based vestibular telerehabilitation before and after surgery, and adding preoperative rotatory chair sessions, can help adults recover balance and reduce dizziness after removal of a unilateral vestibular schwannoma.

  Recruiting Universitat Autonoma de Barcelona · Badalona, Barcelona · NCT07364955

• Testing brain vestibular centers after vestibular schwannoma surgery with MRI

  We’re testing whether brain areas that control balance light up differently in people after vestibular schwannoma surgery compared to healthy individuals using MRI.

  Recruiting Charles University, Czech Republic · Prague · NCT07130851

• Steroids to protect facial nerve function after skull-base surgery for vestibular schwannoma

  This trial tests whether giving steroids after vestibular schwannoma surgery helps preserve facial nerve function compared with a placebo.

  Recruiting Phase 3 Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07116811

• Rehabilitation for patients with vestibular deficits using head impulse testing

  This study is testing a new rehabilitation method using head movement exercises to help people with balance issues from vestibular problems, like vestibular schwannoma, see if it improves their eye and balance function compared to a simple eye movement treatment.

  Recruiting Hospices Civils de Lyon · Bron · NCT06660082

• Gene therapy for vestibular schwannoma treatment

  This study is testing a new gene therapy to see if it can safely help people with growing vestibular schwannomas and severe hearing loss.

  Recruiting at 4 sites Phase 1/2 Eli Lilly and Company · Baltimore, Maryland and 3 other locations · NCT06517888

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.