Using Sodium Bicarbonate Ringer's Solution in Liver Surgery
Official title: The Application of Sodium Bicarbonate Ringer's Solution on Perioperative Lactic Acid Concentration and Early Recovery Quality in Patients Undergoing Laparoscopic Hepatectomy
Run by The First Affiliated Hospital with Nanjing Medical University · NCT05830136 · Data updated 2026-11-12
This study is testing if using sodium bicarbonate Ringer's solution during liver surgery helps patients stay stable compared to the usual lactate Ringer's solution.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | The First Affiliated Hospital with Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Status | Recruiting |
| Started | February 1, 2022 |
| Main results expected | January 1, 2026 |
| Study ends | May 1, 2026 |
| Registry record updated | November 12, 2024 |
| Trial ID | NCT05830136 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older who are scheduled for laparoscopic hepatectomy and can provide informed consent.
✕Probably not a fit
Patients under 18, pregnant women, and those with significant cardiac, pulmonary, or renal conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares the effects of sodium bicarbonate Ringer's solution and lactate Ringer's solution on patients undergoing laparoscopic liver resection. It is a single-center, prospective randomized controlled trial involving 100 patients, who are divided into two groups to assess various hemodynamic and biochemical parameters at different stages of the surgery. The goal is to evaluate the potential advantages of sodium bicarbonate Ringer's solution in maintaining internal balance during the procedure.
Why it matters
Potential benefit: If successful, this approach could improve patient outcomes during laparoscopic liver surgery by optimizing hemodynamic stability.
How similar studies have gone: While the specific application of sodium bicarbonate Ringer's solution in this context may be novel, similar studies have shown promising results with alternative solutions in surgical settings.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. ≥18 years old, 2. patients who plan to undergoing laparoscopic hepatectomy ; 3. Willing to sign informed consent. Exclusion Criteria: 1. age \<18 years 2. pregnancy 3. active cardiac conditions (unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease, history of congestive heart failure) 4. history of significant cerebrovascular disease 5. restrictive or obstructive pulmonary disease 6. uncontrolled hypertension 7. renal dysfunction (glomerular filtration rate \<60 mL/min), 8. evidence of hepatic metabolic disorder (bilirubin \>35 mmol/L) 9. presence of active infection
Where it's running
-
Shijiang Liu
Nanjing, Jiangsu, China Recruiting
Study contacts
- Principal investigator: Shijiang Liu — The First Affiliated Hospital with Nanjing Medical University
- Study coordinator: Shijiang Liu
- Email: liushijiang@jsph.org.cn
- Phone: 02568303569
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.