Using simple sugars to improve health in children with congenital disorders of glycosylation
Dietary Monosaccharide Supplementation in Patients With Congenital Disorders of Glycosylation
This study is testing if giving simple sugars every day can help improve the health of children with congenital disorders of glycosylation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT04198987 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effects of daily dietary supplementation with simple sugars in children diagnosed with congenital disorders of glycosylation (CDG). Researchers will collect data from patients who are currently receiving or planning to receive these sugar supplements to assess their health outcomes. The study seeks to expand the existing evidence regarding the potential benefits of this treatment in clinical practice.
Who should consider this trial
Good fit: Ideal candidates for this study are children with a biochemically and genetically confirmed diagnosis of congenital disorders of glycosylation who are receiving or planning to receive oral simple sugar supplementation.
Not a fit: Patients with conditions such as aldolase B deficiency, galactosemia, hemolytic uremic syndrome, severe anemia, or galactose intolerance may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved health and quality of life for children suffering from congenital disorders of glycosylation.
How similar studies have performed: While this approach is being explored, there is limited existing evidence on the effectiveness of dietary monosaccharide supplementation specifically for congenital disorders of glycosylation, making this study relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient has a biochemically and genetically proven congenital disorder of glycosylation * Patient is receiving (or planning to receive) oral simple sugar supplementation Exclusion Criteria: * Aldolase B deficiency * Galactosemia * Hemolytic uremic syndrome * Severe anemia * Galactose intolerance
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: David Deyle, MD — Mayo Clinic
- Study coordinator: David Deyle, M.D.
- Email: Deyle.David@mayo.edu
- Phone: 507-293-5864
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.