Using Sildenafil Citrate to Improve Frozen Embryo Transfer Success
The Effect of Sildenafil Citrate on the Endometrial Thickness and Pregnancy Rates of Frozen Embryo Transfer Cycles
PHASE2; PHASE3 · Beni-Suef University · NCT05951413
This study is testing whether adding sildenafil citrate to estradiol can help improve the chances of pregnancy for women undergoing frozen embryo transfers by looking at how it affects the lining of the uterus.
Quick facts
| Phase | PHASE2; PHASE3 |
|---|---|
| Study type | Interventional |
| Enrollment | 110 (estimated) |
| Ages | 20 Years to 40 Years |
| Sex | Female |
| Sponsor | Beni-Suef University (other) |
| Locations | 1 site (Banī Suwayf, Beni Suef) |
| Trial ID | NCT05951413 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of sildenafil citrate on endometrial preparation for patients undergoing frozen-thawed embryo transfer. A total of 110 patients will be randomly assigned to two groups: one receiving estradiol alone and the other receiving sildenafil citrate in addition to estradiol. The primary focus is to assess the effect of these treatments on endometrial thickness and subsequent pregnancy rates. Endometrial thickness will be monitored via transvaginal ultrasound throughout the cycle, with adjustments made to medication based on thickness measurements.
Who should consider this trial
Good fit: Ideal candidates are women under 40 years old with high-quality frozen embryos.
Not a fit: Patients with a history of endocrine diseases or previous implantation failures may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance pregnancy rates for patients undergoing frozen embryo transfers.
How similar studies have performed: While the use of sildenafil in reproductive medicine is being explored, this specific approach to frozen embryo transfer is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age under 40 years 2. Subject has high quality frozen embryos Exclusion Criteria: 1-A history of endocrine diseases. 2. A history of any previous surgery that could compromise the integrity of endometrium. 3. Cardiovascular, renal and liver diseases. 4. Hypotension (blood pressure less than 90/50). 5. A history of stroke or myocardial infarction. 6. A history of previous implantation failure.
Where this trial is running
Banī Suwayf, Beni Suef
- Beni-suef university Hospital — Banī Suwayf, Beni Suef, Egypt (RECRUITING)
Study contacts
- Principal investigator: Beni-Suef University — Faculty of Medicine Beni-Suef University
- Study coordinator: Sara A Salem, MD
- Email: sara_abdallah100@yahoo.com
- Phone: 01272842226
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: IVF, Sildenafil, thawed embryo transfer, endometrial thickness