Using Shuxuening Injection to Prevent Complications After Aneurysmal Subarachnoid Hemorrhage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the efficacy of Shuxuening injection in preventing cerebral vasospasm and delayed cerebral ischemia in patients who have undergone treatment for aneurysmal subarachnoid hemorrhage. It is a randomized, double-blind, placebo-controlled trial where participants are divided into two groups: one receiving the Shuxuening injection and the other receiving a placebo. Both groups will also receive standard care as per the latest guidelines. The treatment will be administered intravenously for 10-14 days starting from the first day post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. adult patients (\> 18 years of age)
2. patients who were diagnosed with aneurysmal subarachnoid hemorrhage
3. the aneurysms were treated by microsurgery clipping or endovascular coiling
4. Time from onset to surgery is less than or equal to 72 hours;
5. no new hemorrhage or new infarction on first postoperative CT;
6. signed informed consent.

Exclusion Criteria:

1. mRS \>1 before onset
2. history of microsurgery clipping or endovascular coiling
3. anemia (hemoglobin \<10g/dL), thrombocytopenia (platelet count \<100×10\^9/L), or leukopenia (white blood cell count \<3×10\^9/L) at randomization
4. patients with chronic liver and kidney dysfunction (including those with alanine aminotransferase (ALT) and aliquot aminotransferase (AST) \> 3 times the upper limit of normal, and those with blood creatinine (Scr) \> 2 times the upper limit of normal)
5. patients suffering from cardiorespiratory insufficiency disease such as heart failure, severe heart disease, respiratory failure
6. allergy to Shuxuening Injection
7. those who have used Shuxuening Injection before enrolled
8. patients with end-stage disease, those with a life expectancy of less than 3 months
9. women who are prepare for pregnancy in 3 months, pregnant or breastfeeding
10. those who are participating or have participated in other clinical trials within the past 1 month
11. patients are unable to comply with this study due to mental illness, cognitive or emotional disorders, etc. or that the investigator think patients inappropriate for this study

Where it's running

• Beijing Tiantan Hospital
  Beijing, Beijing, China Recruiting

Study contacts

• Study coordinator: Jun Yang, doctoral
• Email: yangjun4780@163.com
• Phone: 010-18911127316

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.