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Using semaglutide to help teenagers with excess weight lose and maintain weight loss

Weight Maintenance in Adolescents With Obesity; Long-Term Treatment With Semaglutide s.c.2.4 mg Once-weekly

Phase 4 Interventional Novo Nordisk A/S · NCT06571383

This study tests if a weekly injection of semaglutide can help teenagers aged 12 to 15 with excess weight lose weight and keep it off for at least three years.

Quick facts

PhasePhase 4
Study typeInterventional
Enrollment500 (estimated)
Ages12 Years to 15 Years
SexAll
SponsorNovo Nordisk A/S Industry-sponsored
Locations96 sites (Escondido, California and 95 other locations)
Trial IDNCT06571383 on ClinicalTrials.gov

What this trial studies

This study evaluates the effectiveness of semaglutide, a medication administered via weekly injections, in helping adolescents aged 12 to 15 with excess body weight achieve weight loss and maintain that loss over a minimum period of three years. Participants will receive semaglutide treatment while being monitored for their weight and overall health. The study aims to provide insights into the long-term benefits of this treatment for obesity in teenagers.

Who should consider this trial

Good fit: Ideal candidates are adolescents aged 12 to less than 15 years with a BMI at or above the 95th percentile and a body weight greater than 60 kg.

Not a fit: Patients who are prepubertal or have undergone recent obesity treatments, including surgery or weight loss devices, may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could significantly improve weight management and health outcomes for adolescents struggling with obesity.

How similar studies have performed: Other studies have shown promising results with semaglutide for weight management in adults, suggesting potential success in this adolescent population.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion criteria:

* Informed consent obtained before any study-related activities. Study-related activities are any procedures that are carried out as part of the study, including activities to determine suitability for the study:

  1. The parent(s) or legally acceptable representative (LAR) of the participant must sign and date the Informed Consent Form, according to local requirements
  2. The participant must sign and date the Child Assent Form or provide oral assent, according to local requirements
* Age 12 to less than 15 years at the time of signing the informed consent
* BMI greater than or equal to 95th percentile at screening
* Body weight greater than 60 kg at screening

Exclusion criteria:

* Prepubertal status (Tanner stage 1)
* Treatment with any medication prescribed for the indication of obesity or weight management within 90 days before screening
* Previous or planned (during the study period) obesity treatment with surgery or a weight loss device. However, the following are allowed:

  1. Liposuction and/or abdominoplasty, if performed more than 1 year prior to screening
  2. Adjustable gastric banding, if the band has been removed more than 1 year prior to screening
  3. Intragastric balloon, if the balloon has been removed more than 1 year prior to screening
  4. Duodenal-jejunal bypass liner (e.g., Endobarrier), if the sleeve has been removed more than 1 year prior to screening
* Endocrine, hypothalamic, or syndromic obesity
* History of type 1 or type 2 diabetes mellitus

Where this trial is running

Escondido, California and 95 other locations

+46 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Obesity
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.