Using Selinexor with chemotherapy to treat relapsed multiple myeloma

Selinexor in Combination With Chemotherapy to Treat Relapsed/Refractory Multiple Myeloma Patients

This study is testing if adding Selinexor to chemotherapy can help people with relapsed multiple myeloma feel better after their previous treatments.

Quick facts

• Phase: Phase 2
• Study type: Interventional
• Enrollment: 50 (estimated)
• Ages: 18 Years to 75 Years
• Sex: All
• Sponsor: Wuhan Union Hospital, China (Academic / other)
• Drugs / interventions: Chemotherapy, Cyclophosphamide, doxorubicin
• Locations: 5 sites (Zhengzhou, Henan and 4 other locations)
• Trial ID: NCT04877275 on ClinicalTrials.gov

What this trial studies

This is a single-arm, open-label Phase II study evaluating the efficacy and safety of Selinexor (ATG-010) in combination with chemotherapy for patients with relapsed or refractory multiple myeloma who have previously undergone at least one line of therapy. The study consists of two experimental arms: one receiving Selinexor with pegylated liposomal doxorubicin and dexamethasone, and the other receiving Selinexor with cyclophosphamide and dexamethasone. Each treatment cycle lasts four weeks, with a total of 12 cycles planned for participants. The goal is to assess how well this combination therapy works in this patient population.

Who should consider this trial

Good fit: Ideal candidates are adults aged 18 to 75 with relapsed or refractory multiple myeloma who have previously achieved at least partial remission after first-line treatment.

Not a fit: Patients who have not received prior treatment or those with significant non-hematological toxicities may not benefit from this study.

Why it matters

Potential benefit: If successful, this treatment could provide a new effective option for patients with relapsed or refractory multiple myeloma.

How similar studies have performed: Other studies have explored similar combinations of therapies in multiple myeloma, indicating potential for success, though this specific combination is being tested in a novel context.

Eligibility criteria

Inclusion Criteria:

Patients must meet all of the following inclusion criteria to be eligible to enroll in this study:

1. Known and written informed consent (ICF) voluntarily.
2. Age ≥ 18 years and ≤ 75 years.
3. Patients with multiple myeloma who have received first-line treatment (induction, autologous transplantation and maintenance as the same first-line treatment) and achieved at least partial remission in induction.
4. At or after accepting first-line regimen, subjects must have progression disease (PD) recorded which is determined by researcher according to IMWG criteria.
5. Any clinically significant non-hematological toxicities (except for hair loss, peripheral neuropathy, which is otherwise stipulated in Article 13 of the exclusion criteria) that relevant to previous therapies must have resolved to ≤Grade 2 prior to first dose of study drug.
6. Left ventricular ejection fraction（LVEF ）≥50% by an echocardiogram or MUGA scan in 42 days before the first administration
7. Adequate hepatic function: total bilirubin \< 2× upper limit of normal (ULN) (for patients with Gilbert's syndrome, a total bilirubin of \< 3× ULN is required), AST \< 2.5× ULN, and ALT \< 2.5× ULN.
8. Adequate renal function: estimated creatinine clearance ≥ 20 mL/min (calculated using the formula of Cockroft-Gault).
9. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or 2.
10. Measurable MM as defined by at least one of the following:

    1. Serum M-protein (SPEP) ≥ 5 g/L
    2. 24 hours-Urinary M-protein excretion ≥ 0.2 g (200 mg)
    3. Serum FLC ≥ 100 mg/L with abnormal FLC ratio
11. Expected survival is more than 6 months.
12. Adequate hematopoietic function (no platelet transfusion within 2 weeks prior to screening test):

    1. Hemoglobin level ≥ 60 g/L
    2. ANC ≥ 1,000/mm3 (1.0×109/L)
    3. Platelet count ≥ 75,000/mm3 (75×109/L)
13. Female patients of childbearing potential must meet below two criteria:

    1. must agree to use effective contraception methods since signature in ICF, throughout the study and for 3 months following the last dose of study treatment.
    2. must have a negative serum pregnancy test at screening. Note: A woman is considered of childbearing potential following menarche and until becoming postmenopausal (defined as no menstrual period for a minimum of 12 months) or permanently sterile (having undergone a hysterectomy, bilateral salpingectomy or bilateral oophorectomy). A woman who is taking oral contraceptive or using intrauterine device is considered of childbearing potential.
14. Male patients (including those who have received vasectomy) must use a condom if sexually active with a female of child-bearing potential throughout the study and for 3 months following the last dose of study treatment.

Exclusion Criteria:

Patients who meet any of the following criteria will not be enrolled:

1. Asymptomatic (smoldering) MM.
2. Plasma cell leukemia.
3. Documented active amyloidosis.
4. Previously refractory or intolerant to combined drugs.
5. Pregnancy or breastfeeding.
6. Major surgery was performed within 4 weeks prior to the first study.
7. Patients with active, unstable cardiovascular diseases, fits any of the following:

   1. Symptomatic ischemia, or
   2. Uncontrolled clinically-significant conduction abnormalities (e.g., patients with ventricular tachycardia on antiarrhythmics are excluded; patients with first-degree atrioventricular (AV) block or asymptomatic left anterior fascicular block/right bundle branch block (LAFB/RBBB) are allowed), or
   3. Congestive heart failure (CHF) of New York Heart Association (NYHA) ≥ Grade 3, or
   4. Acute myocardial infarction (AMI) within 3 months prior to the first dose of study drug.
8. Uncontrolled active infection within 1 week prior to the first dose of study drug.
9. Known HIV positive.
10. Known active hepatitis A, B, or C infection; or known positive for HCV RNA or HBsAg.

    (Note: patients with HBsAg negative but HBc Ab positive need further HBV-DNA test, excluded if HBV-DNA ≥103 , if HBV-DNA \<103 need anti-viral drugs)
11. Prior malignancy that required treatment or has shown evidence of recurrence (except for skin basal-cell carcinoma and in-situ carcinoma including squamous cell carcinoma, bladder cancer in situ, endometrial cancer in situ, cervical cancer in situ/atypical hyperplasia, prostate cancer incidental finding (T1a or T1b), or breast cancer in situ) within 5 years prior to the first dose of study drug.
12. Active GI dysfunction interfering with the ability to swallow tablets, or any GI dysfunction that could interfere with absorption of study treatment.
13. Grade ≥ 3 peripheral neuropathy, and Grade ≥ 2 painful neuropathy, within 3 weeks prior to the first dose of study drug.
14. Serious, active psychiatric, or medical conditions which, in the opinion of the Investigator, could interfere with study treatment.
15. Participation in an investigational anti-cancer clinical study within 3 weeks or 5 half-lives (T1/2) prior to the first dose of study drug.
16. Received ASCT within 12 weeks prior to the first dose of study drug or previous allogeneic stem cell transplantation (no time limitation).
17. Treatment with an approved or trial anticancer drug was given within 3 weeks or 5 half-lives (T1/2) （With a short time priority） prior to the first study.
18. Prior exposure to a SINE compound.

Where this trial is running

Zhengzhou, Henan and 4 other locations

• Henan Cancer Hospital — Zhengzhou, Henan, China (Recruiting)
• Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology — Wuhan, Hubei, China (Recruiting)
• Zhongnan Hospital of Wuhan University — Wuhan, Hubei, China (Not_yet_recruiting)
• The First Affiliated Hospital of Air Force Medical University — Xi'an, Shanxi, China (Not_yet_recruiting)
• The Second Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shanxi, China (Not_yet_recruiting)

Study contacts

• Principal investigator: Chunyan Sun, M.D., Ph.D — Wuhan Union Hospital, China
• Study coordinator: Chunyan Sun, M.D., Ph.D

Conditions Multiple Myeloma; Selinexor; ATG-010; Relapsed/Refractory Multiple Myeloma