Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Using Scrambler Therapy to treat pain after a stroke

Official title: Scrambler Therapy for Post-Stroke Pain

Run by Johns Hopkins University · NCT05563038 · Data updated 2026-11-12

This study is testing if Scrambler Therapy can help people who have pain after a stroke feel better compared to regular pain medications.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorJohns Hopkins University
Academic / other
Locations1 site (Baltimore, Maryland)
StatusRecruiting
StartedMay 15, 2023
Main results expectedDecember 2027
Study endsDecember 2027
Registry record updatedJanuary 26, 2026
Trial IDNCT05563038 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults over 18 who have experienced an ischemic or hemorrhagic stroke and have pain in areas affected by their stroke.

Probably not a fit

Patients with transient ischemic attacks, no evidence of stroke on MRI, or those with certain medical devices or conditions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of Scrambler Therapy compared to traditional pharmacologic treatments for patients experiencing post-stroke pain. Participants will be enrolled if they are at least one month post-stroke and have pain related to their stroke location. They will choose their preferred treatment method and will be monitored for pain relief over the course of a year using standardized pain scores. The study will compare the maximum pain relief and duration of relief achieved between the two treatment groups.

Why it matters

Potential benefit: If successful, this study could provide an alternative pain management option for patients suffering from post-stroke pain.

How similar studies have gone: While Scrambler Therapy is a novel approach, similar studies have shown promising results in pain management, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men and women over the age of 18 with ischemic or hemorrhagic stroke seen on imaging and a positive finding for pain in the area(s) affected by their stroke location will be included.
* The patients must be at least one month post-stroke but can otherwise enroll at any point.

Exclusion Criteria:

* Patients with TIA
* Patients with no evidence of stroke on MRI
* Patients with implantable devices such as pacemakers, defibrillators, spinal cord stimulators
* Patients with history of myocardial infarction in the past 6 months
* Patients with uncontrolled epilepsy
* Patients with symptomatic brain metastases

Where it's running

  • Johns Hopkins Bayview Hospital
    Baltimore, Maryland, United States
    Recruiting

Study contacts

  • Principal investigator: Dawn Merbach, MNP — Johns Hopkins University
  • Study coordinator: Dawn Merbach, MNP
  • Email: dmerbac1@jhmi.edu
  • Phone: 4105508065

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.