Using Scrambler Therapy to treat pain after a stroke

Scrambler Therapy for Post-Stroke Pain

Not applicable Interventional Johns Hopkins University · NCT05563038

This study is testing if Scrambler Therapy can help people who have pain after a stroke feel better compared to regular pain medications.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment100 (estimated)
Ages18 Years and up
SexAll
SponsorJohns Hopkins University Academic / other
Locations1 site (Baltimore, Maryland)
Trial IDNCT05563038 on ClinicalTrials.gov

What this trial studies

This study aims to evaluate the effectiveness of Scrambler Therapy compared to traditional pharmacologic treatments for patients experiencing post-stroke pain. Participants will be enrolled if they are at least one month post-stroke and have pain related to their stroke location. They will choose their preferred treatment method and will be monitored for pain relief over the course of a year using standardized pain scores. The study will compare the maximum pain relief and duration of relief achieved between the two treatment groups.

Who should consider this trial

Good fit: Ideal candidates are adults over 18 who have experienced an ischemic or hemorrhagic stroke and have pain in areas affected by their stroke.

Not a fit: Patients with transient ischemic attacks, no evidence of stroke on MRI, or those with certain medical devices or conditions may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide an alternative pain management option for patients suffering from post-stroke pain.

How similar studies have performed: While Scrambler Therapy is a novel approach, similar studies have shown promising results in pain management, suggesting potential for success.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men and women over the age of 18 with ischemic or hemorrhagic stroke seen on imaging and a positive finding for pain in the area(s) affected by their stroke location will be included.
* The patients must be at least one month post-stroke but can otherwise enroll at any point.

Exclusion Criteria:

* Patients with TIA
* Patients with no evidence of stroke on MRI
* Patients with implantable devices such as pacemakers, defibrillators, spinal cord stimulators
* Patients with history of myocardial infarction in the past 6 months
* Patients with uncontrolled epilepsy
* Patients with symptomatic brain metastases

Where this trial is running

Baltimore, Maryland

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Post Stroke Pain
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.