Using scalp cooling and hairstyling to prevent hair loss during chemotherapy for patients of color

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of scalp cooling techniques combined with specific hairstyling methods to prevent chemotherapy-induced hair loss in patients of color. It aims to understand the molecular mechanisms and identify predictive biomarkers associated with the success of scalp cooling in individuals with curly or kinky hair types undergoing chemotherapy for breast or non-small cell lung cancer. The study addresses the underrepresentation of minority populations in previous trials and seeks to improve the efficacy of scalp cooling for these patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age \>= 18 years
2. Female
3. Hair type 3 (curly) or type 4 (kinky)
4. Diagnosis of breast cancer or non-small cell lung cancer (NSCLC) or gynecologic cancer stage I-IV
5. Patient will be starting \>= 4 cycles of taxane-based chemotherapy treatment for curative intent after enrollment

   a. Concurrent HER, cisplatin, cyclophosphamide therapies and doxorubicin therapies allowed
6. Eastern Cooperative Oncology Group (ECOG) 0-2: fully active, restrictive in physically strenuous activity, ambulatory and capable of self-care

Exclusion Criteria:

1. Hair type other than 3 or 4
2. Male
3. Use of hair weave or extensions without plans to remove
4. Concurrent malignancy including hematologic malignancies (i.e. leukemia or lymphoma)
5. Alopecia Common Terminology Criteria for Adverse Events \> grade 1 at baseline
6. Past chemotherapy administration if past treatment was \<= 10 years ago
7. History of migraines or cluster headaches, anorexia, severe anemia, uncontrolled diabetes, hepatitis, thyroid dysfunction, cold urticaria, cold agglutinin disease, scalp metastases
8. Planned bone marrow ablation chemotherapy or skull irradiation
9. Pregnant patient

Where it's running

• Montefiore Medical Center
  The Bronx, New York, United States Recruiting

Study contacts

• Principal investigator: Beth McLellan, MD — Montefiore Medical Center
• Study coordinator: Beth McLellan, MD
• Email: bmclella@montefiore.org
• Phone: (718) 862-8840

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.