Using SBRT to treat ventricular tachycardia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of Stereotactic Body Radiotherapy (SBRT) in patients with ventricular tachycardia (VT) who have not responded to conventional treatments. A total of 12 patients will be recruited from a cardiology clinic, where they will undergo comprehensive imaging and mapping to develop a tailored treatment plan. The treatment will be administered using a TrueBeam linear accelerator, and patients will be monitored for outcomes at regular follow-up intervals. The goal is to provide a new therapeutic option for patients suffering from recurrent VT.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Structural heart disease: ischemic or non-ischemic cardiomyopathy diagnosed with cardiac imaging demonstrating either segmental myocardial dysfunction, or presence of scar, AND
* One of the following monomorphic VT events despite prior attempted catheter ablation (or contraindication for ablation), AND despite treatment with a class III antiarrhythmic drug (contraindicated, ineffective or not tolerated): A: Documented sustained monomorphic VT terminated by pharmacologic means, DC cardioversion or manual ICD Therapy. B: ≥3 episodes of monomorphic VT treated with antitachycardia pacing (ATP), at least one of which was symptomatic C: ≥ 5 episodes of monomorphic VT treated with antitachycardia pacing (ATP) regardless of symptoms D: ≥1 appropriate ICD shocks, E: ≥3 monomorphic VT episodes within 24 hours \*\* VT events must be confirmed by ECG/monitor or ICD download.

Exclusion Criteria:

* Unable or unwilling to provide informed consent
* Have received prior radiotherapy to the likely treatment field
* Inotrope-dependent heart failure or an anticipated life-expectancy of \< 1 year in the absence of VT
* Presenting arrhythmia: polymorphic VT or ventricular fibrillation (VF)
* Pregnancy
* Active ischemia (acute thrombus diagnosed by coronary angiography, or dynamic ST segment changes demonstrated on ECG) or another reversible cause of VT (e.g. drug-induced arrhythmia), had recent acute coronary syndrome within 30 days thought to be due to acute coronary arterial thrombosis, or have CCS functional class IV angina. Note that biomarker level elevation alone after ventricular arrhythmias does not denote acute coronary syndrome or active ischemia.

Where it's running

• Nova Scotia Health Authority
  Halifax, Nova Scotia, Canada Recruiting

Study contacts

• Principal investigator: John Sapp, MD FRCPC — Nova Scotia Health Authority
• Study coordinator: Karen Giddens
• Email: karen.giddensl@nshealth.ca
• Phone: 902 237-5551

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.