Using SBRT to treat spinal metastases from solid tumors
The Efficiency of SBRT in Preventing Recurrent Spinal Cord Compression in Patients Undergoing Surgery and Radiotherapy for Epidural Spinal Metastasis From Solid Tumor
This study is testing if a special type of radiation treatment called SBRT can help people with spinal tumors that are pressing on their spinal cord feel better and improve their quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven, Vlaams Brabant) |
| Trial ID | NCT04863612 on ClinicalTrials.gov |
What this trial studies
This study aims to document the effectiveness of Stereotactic Body Radiotherapy (SBRT) in managing spinal metastases with imminent or actual spinal cord compression. Patients undergoing surgery followed by SBRT will be monitored for neurological outcomes, performance, and quality of life. The results will be compared to historical data from patients treated with conventional radiotherapy at the same institution. The study is observational and seeks to enhance understanding of SBRT's role in this clinical context.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 with spinal metastases from solid tumors and evidence of spinal cord compression.
Not a fit: Patients with prior radiotherapy at the same spinal level or those with conditions affecting data reliability may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could improve neurological outcomes and quality of life for patients with spinal metastases.
How similar studies have performed: Previous studies have shown promising results with SBRT in similar contexts, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Radiological diagnosis of spinal metastasis from solid tumor with epidural imminent or actual spinal cord compression, with or without neurological deficits. Patients will be scheduled for surgery + SBRT. If contra-indications preclude surgery and only SBRT is performed, patients will still be included. * Written informed consent to participate in the study must be obtained from the subject or proxy /legal representative * Males and females \> 18 years Exclusion Criteria: * Any concomitant condition or disease which, in the opinion of the investigator, would affect the reliability of the collected data. * Patients that had previous radiotherapy on the index spinal level without the possibility for additional SBRT at that particular level.
Where this trial is running
Leuven, Vlaams Brabant
- University hospital Leuven — Leuven, Vlaams Brabant, Belgium (Recruiting)
Study contacts
- Principal investigator: Bart Depreitere, MD, PhD — UZ Leuven
- Study coordinator: Bart Depreitere, Phd, MD
- Email: bart.depreitere@uzleuven.be
- Phone: +3216344290
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.