Using SBRT to treat spinal metastases from solid tumors
Official title: The Efficiency of SBRT in Preventing Recurrent Spinal Cord Compression in Patients Undergoing Surgery and Radiotherapy for Epidural Spinal Metastasis From Solid Tumor
Run by Universitaire Ziekenhuizen KU Leuven · NCT04863612 · Data updated 2026-11-12
This study is testing if a special type of radiation treatment called SBRT can help people with spinal tumors that are pressing on their spinal cord feel better and improve their quality of life.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven, Vlaams Brabant) |
| Status | Recruiting |
| Started | May 18, 2021 |
| Main results expected | March 1, 2031 |
| Study ends | March 1, 2036 |
| Registry record updated | December 29, 2023 |
| Trial ID | NCT04863612 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults over 18 with spinal metastases from solid tumors and evidence of spinal cord compression.
✕Probably not a fit
Patients with prior radiotherapy at the same spinal level or those with conditions affecting data reliability may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to document the effectiveness of Stereotactic Body Radiotherapy (SBRT) in managing spinal metastases with imminent or actual spinal cord compression. Patients undergoing surgery followed by SBRT will be monitored for neurological outcomes, performance, and quality of life. The results will be compared to historical data from patients treated with conventional radiotherapy at the same institution. The study is observational and seeks to enhance understanding of SBRT's role in this clinical context.
Why it matters
Potential benefit: If successful, this approach could improve neurological outcomes and quality of life for patients with spinal metastases.
How similar studies have gone: Previous studies have shown promising results with SBRT in similar contexts, indicating potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Radiological diagnosis of spinal metastasis from solid tumor with epidural imminent or actual spinal cord compression, with or without neurological deficits. Patients will be scheduled for surgery + SBRT. If contra-indications preclude surgery and only SBRT is performed, patients will still be included. * Written informed consent to participate in the study must be obtained from the subject or proxy /legal representative * Males and females \> 18 years Exclusion Criteria: * Any concomitant condition or disease which, in the opinion of the investigator, would affect the reliability of the collected data. * Patients that had previous radiotherapy on the index spinal level without the possibility for additional SBRT at that particular level.
Where it's running
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University hospital Leuven
Leuven, Vlaams Brabant, Belgium Recruiting
Study contacts
- Principal investigator: Bart Depreitere, MD, PhD — UZ Leuven
- Study coordinator: Bart Depreitere, Phd, MD
- Email: bart.depreitere@uzleuven.be
- Phone: +3216344290
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Stereotactic body radiation therapy for spinal metastases with epidural compression
This study tests whether SBRT can safely help adults with spinal metastases that compress the spinal cord see if the treatment works in reducing issues from their cancer.
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Postoperative Edge SBRT for Spinal Metastases
This observational study tests whether high-precision postoperative SBRT with the Edge system can improve local control and neurological outcomes in patients with spinal metastases after surgery.
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Radiotherapy after Separation Surgery for Spinal Metastases
This study tests whether giving radiotherapy after separation surgery helps people with spinal metastases live longer and feel better.
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Focused high-dose SBRT for spinal tumors
This program will try focused high-dose SBRT for adults with spinal metastases to track side effects and local tumor control during routine care.
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Pre-surgery focused radiation for spinal metastases.
This trial will test whether short-course, focused radiation given before surgery can improve local tumor control and reduce pain and disability in adults with spinal metastases.
-
Evaluating autologous blood transfusion in spinal surgery for lung cancer with spinal metastasis
This study is testing whether using a patient's own blood during spinal surgery for lung cancer with spinal metastases is safer and more effective than using donated blood.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.