Using rTMS to treat patients with disorders of consciousness
Targeting Anterior or Posterior, Where is Better for DOC
This study is testing if a special brain stimulation treatment can help improve alertness and awareness in patients with disorders of consciousness caused by brain injuries.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 84 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Zhujiang Hospital Academic / other |
| Locations | 1 site (Guangzhou, Guangzhou) |
| Trial ID | NCT06527573 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on patients with disorders of consciousness, which can result from brain injuries. The research aims to compare the outcomes of active rTMS versus sham stimulation to assess improvements in alertness and awareness. Patients will be carefully selected based on specific inclusion and exclusion criteria, ensuring that those with stable conditions and no contraindications for rTMS are enrolled. The study seeks to understand how targeted brain stimulation can influence recovery in these patients.
Who should consider this trial
Good fit: Ideal candidates are individuals with acquired brain injuries who have been diagnosed with a disorder of consciousness within the specified time frame.
Not a fit: Patients with uncontrolled epilepsy, certain metallic implants, or those currently participating in other neuroregulation trials may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance recovery and improve the quality of life for patients with disorders of consciousness.
How similar studies have performed: While the use of rTMS in similar contexts is emerging, this specific approach targeting disorders of consciousness is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. acquired brain injuries less than 1 year and more than 28 days in DOC; 2. clinical diagnosis of DOC Disease; 3. no medical history of neuropsychiatric diseases; 4. no contraindications for rTMS or EEG, no sedatives in use or other drugs that might interfere with brain stimulation, such as Na+ or Ca2+ channel blockers or NMDA receptor antagonists; 5. stable state of disease and vital signs; 6. the integrity of the individualized stimulation target cortex are verified by MRI. Exclusion Criteria: 1. patients in other non-invasive or invasive neuroregulation trials; 2. motor evoked potential (MEP) in M1 region cannot be induced by TMS pulse; 3. uncontrolled epilepsy, seizure within 4 weeks before enrollment; 4. metallic implant in the skull, pacemaker, craniotomy under the stimulated site, implanted brain device.
Where this trial is running
Guangzhou, Guangzhou
- Zhujiang Hospital of Southern Medical University — Guangzhou, Guangzhou, China (Recruiting)
Study contacts
- Study coordinator: ziqin Liao, BSc
- Email: ziqinliao1997@163.com
- Phone: 15079991339
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.