Using rTMS to prevent and treat cognitive issues after surgery
Clinical Study of Repeated Transcranial Magnetic Stimulation in the Prevention and Treatment of Postoperative Executive Dysfunction
This study is testing if a treatment called rTMS can help people who have trouble thinking clearly after heart valve replacement surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 400 (estimated) |
| Ages | 45 Years to 75 Years |
| Sex | All |
| Sponsor | Xuzhou Central Hospital Academic / other |
| Locations | 1 site (Xuzhou, Jiangsu) |
| Trial ID | NCT05575583 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on patients experiencing postoperative cognitive dysfunction (POCD) following heart valve replacement surgery. By utilizing neuroimaging techniques, the study aims to explore the relationship between neuroinflammation and brain network abnormalities in these patients. The goal is to assess how rTMS can repair pathological changes associated with POCD, potentially leading to improved cognitive outcomes. The findings may help refine rTMS treatment protocols for better management of cognitive dysfunction after surgery.
Who should consider this trial
Good fit: Ideal candidates are adults aged 45 to 75 who are undergoing heart valve replacement surgery.
Not a fit: Patients with severe neuropsychiatric disorders or significant organ failure may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly enhance cognitive recovery in patients after heart surgery.
How similar studies have performed: Previous studies have shown that rTMS can improve cognitive function post-surgery, indicating potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Heart valve replacement. * 45 to 75 years old. Exclusion Criteria: * definite cerebral infarction. * failure and decompensation of vital organs * physical metal implants. * severe neuropsychiatric disorders. * less than 9 years of education. * alcohol abuse. * drug dependence.
Where this trial is running
Xuzhou, Jiangsu
- Xuzhou Central Hospital — Xuzhou, Jiangsu, China (Recruiting)
Study contacts
- Principal investigator: Yangzi Zhu, Doctor — Xuzhou Central Hospital
- Study coordinator: Liwei Wang, Doctor
- Email: doctorlww@sina.com
- Phone: +86 18952170255
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.