Using rTMS guided by MEG to treat migraines

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of repetitive transcranial magnetic stimulation (rTMS) guided by magnetoencephalography (MEG) in treating migraine patients. Participants will be randomly assigned to receive either the rTMS treatment or the traditional medication Sibelium. The study will assess clinical efficacy based on headache frequency, severity, duration, and analgesic use, while also analyzing genetic correlations with treatment outcomes. The goal is to explore innovative approaches for migraine management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Complies with specific disease diagnosis: A. Headaches that meet the criteria of B and C (headaches that meet the characteristics of tension headaches or migraines) should occur at least 15 days per month and last for at least 3 months; B. Headaches that meet the criteria of 1.1 migraine without aura diagnosis B-D or 1.2 migraine with aura B and C occurring at least 5 times; C. Headache meets any of the following criteria and occurs for more than 8 days per month, lasting for more than 3 months: ①1.1 C and D of migraine without aura②1.2 B and C of migraine with aura③ The migraine attack perceived by the patient can be relieved by taking triptan or ergot, which cannot be better explained by other diagnoses in ICHD-3.
* Must be able to swallow tablets
* Signed and dated informed consent form Promise to comply with research procedures and cooperate in implementing the entire research process

Exclusion Criteria:

* Age under 15 years old; Accompanied by optic disc edema, focal symptoms and signs of the nervous system (except for typical visual and sensory precursors) or cognitive impairment; Sudden and rapidly peaking severe headaches (thunderous headaches)
* Accompanied by fever; New onset headaches in adults, especially after the age of 50; Headaches in patients with high coagulation risk
* New headache in patients with tumor or AIDS history; Headaches related to changes in body position;
* History of epileptic seizures

Where it's running

• Ruijin Hospital
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Xiaodan Wang, Doctor
• Email: wxd12466@rjh.com.cn
• Phone: +86-21-64370045

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.