Using retinal markers to predict disease progression in neuroinflammatory diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the predictive value of retinal markers in patients with Multiple Sclerosis and other neuroinflammatory diseases, as well as healthy controls. Participants will undergo non-invasive retinal examinations and complete a questionnaire to assess various retinal measures. The focus is on identifying neuroaxonal loss and neuroinflammation in the retina, which may indicate progression independent of relapse activity (PIRA). The study seeks to improve early identification of patients at risk for PIRA, which is crucial for effective management of Multiple Sclerosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. All groups:

   * Age \>18 years old
2. Patients with Multiple Sclerosis:

   * Diagnosis of Multiple Sclerosis, according to the last revisions of the McDonald Criteria (2017)
3. Patients with other neuroinflammatory diseases:

   * Diagnosis of Neuromyelitis optica spectrum disorder or Myelin oligodendrocyte glycoprotein antibody disease or other neuroinflammatory disorders other than Multiple Sclerosis

Exclusion Criteria:

1. All groups:

   * Inability to undergo Optical Coherence Tomography (OCT) and/or retinal vessel imaging (e.g. severe nystagmus that prevents eye fixation on both eyes)
   * Presence of any ocular pathology that may interfere with the validity of the OCT/retinal vessel analysis (cataracts, glaucoma, history of refractive defects \>6 D etc.).
   * Pregnancy and Lactation
2. Healthy Controls

   * History of other neurological conditions: participants with a history of other significant neurological conditions that might interfere with the assessment or interpretation of the signs and symptoms will be excluded (e.g. confirmed Stroke, Acute disseminated encephalomyelitis, Chronic inflammatory Demyelinating Disease, Polyneuropathy, etc.)

Where it's running

• University Hospital Basel, Department of Neurology
  Basel, Switzerland Recruiting

Study contacts

• Principal investigator: Athina Papadopoulou, PD Dr. med. — University Hospital Basel, Department of Neurology
• Study coordinator: Athina Papadopoulou, PD Dr. med.
• Email: Athina.Papadopoulou@usb.ch
• Phone: +41 61 32 85704

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.