Using Resveratrol Gel to Reduce Pain After Gum Surgery
Official title: Efficacy of Resveratrol-Based Gel Versus Hyaluronic Acid Gel as a Palatal Wound Dressing Materials on Postoperative Pain Following Free Gingival Graft Surgery: A Randomized Controlled Clinical Trial
Run by Cairo University · NCT06521333 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing whether a Resveratrol gel can help reduce pain after gum surgery better than a Hyaluronic acid gel.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06521333 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are systemically healthy adults over 18 years old with mucogingival defects scheduled for free gingival graft surgery.
✕Probably not a fit
Patients who are pregnant, breastfeeding, smokers, or have allergies to the materials used will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to compare the effectiveness of a Resveratrol-based gel versus a 0.2% Hyaluronic acid gel applied to the palatal donor site following free gingival graft surgery. The approach involves a comprehensive periodontal treatment prior to surgery, followed by the harvesting of a free gingival graft from the palate. Post-operative pain management will be assessed by applying either gel or an acrylic resin stent alone to the surgical site. The goal is to determine which treatment option provides better pain relief after the procedure.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing gum surgery.
How similar studies have gone: While there is limited data on the specific use of Resveratrol gel in this context, similar studies have shown promise in using alternative gels for post-operative pain management.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patient over 18 years of age 2. Systemically healthy 3. Plaque index (PI) and gingival index (GI) less than 15% (Silness \& Löe) 4. Patients with Mucogingival defects scheduled for free gingival graft Exclusion Criteria: 1. Pregnancy or breastfeeding. 2. Occlusal trauma at site of graft. 3. Severe gagging reflex 4. Smokers. 5. Patients allergic to the used materials.
Where it's running
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Faculty of dentistry, Cairo University
Cairo, Egypt Recruiting
Study contacts
- Principal investigator: Liza S ALhakam — master student.
- Study coordinator: Liza S ALhakam, BDS
- Email: liza.alhakam@dentistry.cu.edu.eg
- Phone: 01555325810
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Active oxygen gel vs hyaluronic acid gel for palatal healing after graft harvest
This randomized trial tests whether active oxygen gel or hyaluronic acid gel, each used with a protective dressing, improve palatal wound healing after a free gingival graft compared with a standard gelatin sponge dressing.
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Gum tissue build-up at a missing-tooth pontic site with or without a fixed partial denture
We will test whether connective tissue grafts can improve gum thickness and contour at a single missing-tooth site in adults, comparing sites that have an existing fixed partial denture to sites without one.
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Managing pain after free gingival graft harvesting with Ora-Aid versus an acrylic palatal stent
This trial will test whether an Ora-Aid hydrogel dressing or an acrylic palatal stent better reduces pain for adults after free gingival graft donor-site harvesting.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.