Using remote ischemic preconditioning to prevent kidney injury during coronary angiograms

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of remote ischemic preconditioning (RIPC) as a preventive measure against contrast-induced acute kidney injury (CI-AKI) in patients undergoing coronary angiograms. CI-AKI is a significant risk associated with the use of contrast media during imaging procedures, leading to serious health complications. The study aims to determine if RIPC can reduce the rise in creatinine levels and the incidence of renal replacement therapy in moderate to high-risk patients. By employing a non-invasive and low-cost approach, the research seeks to establish a safe method to mitigate the risks of CI-AKI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* (1) Patients undergoing an interventional or diagnostic radiological procedure in which they receive intravascular contrast, including patients undergoing coronary angiogram +/- percutaneous coronary intervention (PCI) for all clinical indications except those indicated for primary PCI due to STEMI
* (2) patients presenting with a renal clearance in the range of less than 60 ml/min/1.73 m2 but not declared ESRD
* (3) Patients who are not yet recruited for other pharmacological or medical device clinical trials.

Exclusion Criteria:

* (1) Age \<18 years
* (2) Patient on hemodialysis or peritoneal dialysis
* (3) Simultaneous participation in another interventional study
* (4) Percutaneous coiling/embolization procedures of the kidney
* (5) Impossibility to perform RIPC, caused by pathology in both arms (e.g. dystrophy, recent trauma, chronic wounds)
* (6) No written informed consent
* (7) Urgent angiography in STEMI
* (8) Cardiogenic shock requiring catecholamine infusion
* (9) Systolic blood pressure \<80 mmHg
* (10) Intra-aortic balloon counter-pulsation
* (11) Contrast medium injection within the previous 30 days
* (12) Expected impossibility to obtain follow-up data at 6-week follow-up
* (13) Patients with Raynaud's disease

Where it's running

• University of Texas- Medical Branch (UTMB)
  Galveston, Texas, United States Recruiting

Study contacts

• Study coordinator: Salman Salehin, MD
• Email: sasalehi@utmb.edu
• Phone: +12818189321

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.