Using remote ischemic preconditioning to improve kidney transplant outcomes
Official title: Remote Ischaemic Preconditioning in Transplantation (RIPTRANS) - A Prospective Randomized Controlled Trial
Run by Helsinki University Central Hospital · NCT03855722 · Data updated 2026-11-12
This study is testing if a special treatment given to organ donors can help kidney transplants work better and faster for the recipients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 496 (estimated) |
| Sponsor | Helsinki University Central Hospital Academic / other |
| Locations | 1 site (Helsinki) |
| Status | Recruiting |
| Started | March 12, 2019 |
| Main results expected | March 2022 |
| Study ends | February 2042 |
| Registry record updated | March 10, 2020 |
| Trial ID | NCT03855722 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adult organ recipients over 18 years old receiving kidneys from brain-dead donors at Helsinki University Hospital.
✕Probably not a fit
Patients who are hemodynamically unstable, under 18 years old, or participating in another prospective trial may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the effects of remote ischemic preconditioning (RIPC) on kidney transplant outcomes by applying RIPC to brain-dead organ donors. The primary goal is to determine if RIPC can reduce the rate of delayed graft function in kidney transplants. Participants will include organ donors and their corresponding organ recipients, with a focus on those undergoing transplantation at Helsinki University Hospital. The study will compare outcomes between those receiving RIPC and those receiving a sham treatment.
Why it matters
Potential benefit: If successful, this approach could lead to improved kidney transplant outcomes and reduced complications for recipients.
How similar studies have gone: While RIPC has shown promise in animal models and heart surgery, its application in transplantation is less studied, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Donor Inclusion Criteria: * Brain-dead organ donor with a plan of harvesting at least one kidney Donor Exclusion Criteria: * Haemodynamically unstable donor * Age below 18 years * Planned organ recipients are recruited to another prospective trial, which prevents participation in this trial. All organ recipients receiving organs (kidney, liver, pancreas-kidney, heart, lungs) from a randomized donor will be recruited providing that the recipient surgery is performed at Helsinki University Hospital, recipient is over 18 years old, and recipient gives written informed consent to participate in the trial.
Where it's running
-
Helsinki University Hospital
Helsinki, Finland Recruiting
Study contacts
- Principal investigator: Aki Uutela, MD — Helsinki University Central Hospital
- Study coordinator: Ville Sallinen, MD, PhD
- Email: ville.sallinen@helsinki.fi
- Phone: +358-9-4711
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.